Evaluating the quality consistency of compound Liangmianzhen buccal tablets during accessories replacement by HPLC/UV related with its active profiling and UV dissolution profiles  

作　　者：Yue Yu Hanxiao Chi Guoxiang Sun Fangliang Yang Wanyang Sun Jiayue Hu Yanhua Zhang 

机构地区：[1]School of Pharmacy,Shenyang Pharmaceutical University,103 Wenhua Road,Shenyang,Liaoning 110016,China [2]Institute of Traditional Chinese Medicine and Natural Products,College of Pharmacy,Jinan University,Guangdong 510632,China [3]Beijing University of Chemistry Technology,Beijing 100029,China [4]Guangxi Zhuang Autonomous Region Huahong Pharmaceutical Co.,Ltd.,Guangxi 545000,China

出　　处：《Asian Journal of Traditional Medicines》2020年第1期8-23,共16页亚洲传统医药（英文）

基　　金：This research work was financially supported by National Natural Science Foundation of China(Accession No.81573586,No.90612002).

摘　　要：Compound Liangmianzhen buccal tablet is a drug that exhibits notable effect on cough and diphtheria.Since the accessory has been changed,along with the difficulties in traditional Chinese drug-evaluation,it is imperative to set up a reliable method to evaluate the drug and ensure the quality consistency.First,the content of the Compound Liangmianzhen buccal tablets reflected by fingerprints were evaluated by the comprehensive linearly quantified fingerprint method and systematic quantified fingerprint method,in which thirteen fingerprint peaks was selected and gallic acid was chosen as the reference peak.The results of the two methods showed all batches in grades 1–3 of above good level with the qualitative similarities of Sl and Sm above 0.90,and the quantitative ones of Pl%and Pm%from 80%–120%,indicating all samples far qualified.Second,the measurement of antioxidant effect based on DPPH free radical clearance test has demonstrated the consistency between the old prescription group and the new ones and further dug up the major antioxidant compositions.Third,dissolution profiles at 190 to 400 nm that evaluate the curative effect consistency were evaluated by f2 and the correlation of the dissolution curve.In conclusion,the combination of 3 kinds of analysis methods can comprehensively assess the quality of the traditional Chinese drug and be served as a routine procedure to evaluate the herbal medicine consistency.

关 键 词：accessory change FINGERPRINT antioxidant activity dissolution profiling 

分 类 号：R28[医药卫生—中药学]