半乳糖凝集素3对心力衰竭诊断价值的Meta分析  

Diagnostic value of galectin 3 to heart failure: a Meta-analysis

作　　者：张记收 王梦龙[1] 刘剑芳[1] 叶晶[1] 王震[1] 徐瑶[1] 姜慧敏[1] 叶迪 万军[1] Zhang Jishou;Wang Menglong;LiuJianfang;Ye Jing;Wang Zhen;Xu Yao;Jiang Huimin;Ye Di;Wan Jun(Department of Cardiology,People's Hospital,Cardiovascular Disease Institute,Hubei Provincial Key Laboratory of Cardiovascular Disease,Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院心内科武汉大学心血管病研究所心血管病湖北省重点实验室

出　　处：《中国循证心血管医学杂志》2020年第1期14-17,23,共5页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的采用Meta分析评估半乳糖凝集素3对心力衰竭(心衰)的诊断价值。方法检索PubMed、EMbase、万方数据库和中国知网自数据库建库开始至2018年11月30日之前收录的关于半乳糖凝集素3对心力衰竭(心衰)诊断效能的中英文文献并提取数据,使用诊断准确性研究的质量评价工具-2(QUADAS-2)对纳入文献进行质量评估,采用MetaDiSc1.4软件全面分析半乳糖凝集素3诊断心力衰竭的价值。结果共纳入文献14篇,纳入研究存在非阈值效应引起的异质性,采用随机效应模型合并结果,合并灵敏度为0.78(95%CI:0.76~0.80);合并特异度为0.65(95%CI:0.63~0.68);合并阳性似然比为2.85(95%CI:2.07~3.92);合并阴性似然比0.28(95%CI:0.21~0.39);合并诊断比值比(DOR)为12.48(95%CI:6.48~24.06);ROC曲线下面积(AUC)为0.8531。结论半乳糖凝集素3对心衰有中等偏高程度的诊断价值,但仍需要设计合理的大样本研究来证明。Objective To review the diagnostic value of galectin-3(Gal-3)to heart failure(HF)by applying Meta-analysis.Methods The databases of PubMed,EMbase,WanFang Data and CNKI were retrieved for searching the Chinese and English documents about the diagnostic efficacy of Gal-3 to HF from database establishing time to Nov.30,2018,and data was extracted.The quality of included documents was reviewed by using quality assessment of diagnostic accuracy studies-2(QUADAS-2)for study the diagnostic accuracy.The diagnostic value of Gal-3 to HF was comprehensively analyzed by using MetaDiSc1.4 software.Results There were totally 14 documents included,which had the heterogeneity caused by non-threshold effect.A randomized effect model was used to combine results of diagnostic value of Gal-3 to HF,and the results showed that the combined sensitivity was 0.78(95%CI:0.76~0.80),combined specificity was 0.65(95%CI:0.63~0.68),combined positive likelihood ratio was 2.85(95%CI:2.07~3.92),combined negative likelihood ratio was 0.28(95%CI:0.21~0.39),combined diagnostic odds ratio(DOR)was 12.48(95%CI:6.48-24.06),and AUC under ROC was 0.8531.Conclusion Gal-3 has approximately higher diagnostic value to HF,while the conclusion is needed to be certified by the study with large sample and reasonable design.

关 键 词：半乳糖凝集素3 心力衰竭 META分析 

分 类 号：R541.61[医药卫生—心血管疾病]