血DAPK和MGMT DNA水平对肺癌转移的相关性  

Correlation between Serum DAPK,MGMT DNA Methylation and Pathological Metastasis Features of Lung Cancer

作　　者：马会博 杜晶晶 

机构地区：[1]黑龙江省哈尔滨医科大学第二临床医学院检验科,150001 [2]哈尔滨医科大学第一临床医学院输血科

出　　处：《临床输血与检验》2020年第1期51-54,共4页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的 探讨血DAPK和MGMT DNA水平对肺癌病理特征的相关性。方法 研究时间为2015年1月~2018年2月,采用回顾性总结研究方法,选择在我院诊治的非小细胞肺癌(NSCLC)患者78例作为观察组,同期选择在我院进行健康体检的健康人100例作为对照组,采集两组入选者的外周血标本,检测血DNA甲基化分子标志物-DAPK和MGMT水平。结果 观察组中血浆样本中的DAPK和MGMT甲基化比例为51.3%和53.8%,对照组分别为14.0%和15.0%,观察组显著高于对照组(P<0.05)。在观察组中,血浆DAPK和MGMT甲基化与病理组织学类型、淋巴结转移、远端转移有显著相关性(P<0.05)。结论 DAPK和MGMT甲基化与NSCLC患者病理特征有显著相关性。Objective To explore the correlation between serum DAPK,MGMT DNA methylation and pathological metastasis features of lung cancer.Methods From January 2015 to February 2018,78 cases of non small cell lung cancer (NSCLC) were selected as observation group,and 100 healthy people as the control group at the same time in our hospital.The peripheral blood samples of two groups were collected,the plasma DNA methylation molecular markers-DAPK and MGMT levels were detected.Results The proportion of DAPK and MGMT methylation in the plasma samplesin the observation group were 51.3% and 53.8%,and those in the control group were 14% and 15% respectively,and observation group were significantly higher than those in the control group (P<0.05).In the observation group,there were significant correlation between plasma DAPK and MGMT methylation and histopathological type,lymph node metastasis and distal metastasis (P<0.05).Conclusion There are significant correlation between DAPK,MGMT methylation and the pathological features in the NSCLC patients.

关 键 词：DNA甲基化 分子标志物 非小细胞肺癌 淋巴结转移 远端转移 

分 类 号：R392.11[医药卫生—免疫学] R734.2[医药卫生—基础医学]