白蛋白介导的siRNA药物递送系统研究进展  

Albumin-mediated siRNA drug delivery system:research advances

作　　者：龚莉 鲁丹丹 杨静[2] 朱庆均[1,3,4] GONG Li;LU Dan-dan;YANG Jing;ZHU Qing-jun(Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Institute of Radiation Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China;Key Laboratory of TCM Classical Theory,Ministry of Education,Jinan 250355,China;Antiviral Synergistic Innovation Center of Traditional Chinese Medicine in Universities of Shandong,Jinan 250355,China)

机构地区：[1]山东中医药大学,济南250355 [2]军事科学院军事医学研究院辐射医学研究所,北京100850 [3]教育部中医药经典理论研究重点实验室,济南250355 [4]山东省高校中医药抗病毒协同创新中心,济南250355

出　　处：《国际药学研究杂志》2019年第11期805-812,共8页Journal of International Pharmaceutical Research

基　　金：国家“重大新药创制”科技重大专项资助项目(2017ZX09303013-003);国家自然科学基金青年科学基金资助项目(81703429);山东中医药大学药学院“药苑育研”优秀研究生创新基金资助项目(YXY20190207)

摘　　要：小干扰RNA(siRNA)药物是核酸药物的一种,因其特异性强而备受关注,此类药物应用前景广泛,尤其在抗肿瘤领域具有巨大潜力。但由于其本质属于核酸药物,具有核酸药物在应用中的局限性:生物学稳定性差、易被体内的核酸酶降解,导致其生物利用度差,限制了其发展。因此,有许多研究致力于开发siRNA药物体内递送系统,其中白蛋白作为人体血浆中含量最丰富的蛋白质受到广泛关注。白蛋白无免疫原性、循环半衰期长、易与各种药物结合且能在实体瘤中积聚,这些特性使其有望成为siRNA药物的有效递送载体。本文对siRNA药物的研究现状以及血清白蛋白作为siRNA药物递送载体的研究进展进行了回顾和综述。Small interfering RNA(siRNA)drugs,a type of nucleic acid drugs,have attracted much attention be⁃cause of their strong specificity.The siRNA drugs have a broad prospect of therapeutic applications,especially in the an⁃ti-tumor treatment.However,because the siRNA drugs are essentially nucleotide-based,they have also the same limita⁃tions as other nucleic acid drugs in application.They are biologically unstable and susceptible to nuclease in vivo,result⁃ing in poor bioavailability,which restricts their development.Therefore,many studies have been devoted to the develop⁃ment of siRNA drug delivery systems.As the most abundant protein in human plasma,serum albumin has been widely studied.Albumin has a long circulatory half-life and is non-immunogenic and easy to combine with various kinds of drugs to accumulate in solid tumors.These characteristics make albumin an effective delivery vehicle for siRNA drugs.The re⁃search progress in siRNA drugs and serum albumin as siRNA drugs delivery vehicles is reviewed in this paper.

关 键 词：血清白蛋白 小干扰RNA(siRNA) 药物递送系统 

分 类 号：R94[医药卫生—药剂学]