登革热并肝损害的临床特征分析  

Analysis of clinical features of dengue fever with liver damage

作　　者：程家喜 石梅彬[1] 杨洁 黄祥亚[1] 李巧珊 CHENG Jia-xi;SHI Mei-bin;YANG Jie(Department of infection,Xiaolan People's Hospital of Zhongshan,528415,China)

机构地区：[1]中山市小榄人民医院感染科

出　　处：《中国处方药》2020年第2期159-160,共2页Journal of China Prescription Drug

摘　　要：目的探讨登革热并肝损害的临床特征。方法回顾性分析2018年8月~12月某院感染科157例登革热住院患者的临床资料。结果肝损害88例(56.1%),其中血清丙氨酸转氨酶(ALT)升高53例(33.8%),血清天冬氨酸转氨酶(AST)升高86例(54.8%);71例(80.7%)患者肝功2周内可恢复正常,其余患者1月时复查均正常。ALT升高跟患者的血小板减低、年龄增长相关(P值分别是0.000、0.001),Cut-off分别为43、64;AST升高跟患者血小板减低相关(P=0.018),Cut-off为97。结论登革热肝损害与血小板减少、年龄增长密切相关,与性别、白细胞、降钙素原无关;成年人较儿童更易合并肝损害。Objective To investigate the clinical features of dengue fever with liver damage.Methods The clinical data of 157 hospitalized patients with dengue fever in our hospital from August to December 2018 were retrospectively analyzed.Results There were 88 cases(56.1%)with liver damage,including serum alanine aminotransferase(ALT)increased in 53 cases(33.8%),serum aspartate aminotransferase(AST)increased in 86 cases(54.8%);71 cases(80.7%)of the patient's liver function returned to normal within 2 weeks,and the remaining patients were going to be normal at 1 month.Increased ALT was associated with thrombocytopenia and aging in patients(P=0.000,0.001),Cut-off was 43,64;AST elevation was associated with thrombocytopenia(P=0.018)and Cut-off was 97.Conclusion The dengue fever with liver damage is closely related to thrombocytopenia and aging,and is not related to gender,white blood cells and procalcitonin.Adults with dengue fever are more likely to have liver damage than children.

关 键 词：登革热 肝损害 丙氨酸氨基转氨酶 天门冬氨酸氨基转移酶 

分 类 号：R512.8[医药卫生—内科学] R575[医药卫生—临床医学]