112例HIV/AIDS病人合并外科疾病的治疗分析  

Analysis on the treatment of 112 patients with HIV/AIDS complicated with surgical diseases

作　　者：吴金伟 邓建宁[1] 吴锋耀[2] 马杰[3] 李志强[3] WU Jinwei;DENG Jianning;WU Fengyao;MA Jie;LI Zhiqiang(Department of Infection Surgery,Nanning Municipal No.4 People's Hospital,Nanning 530023,Guangxi,China;Anesthesiology Department,Nanning Municipal No.4 People's Hospital,Nanning 530023,Guangxi,China;Surgery Department,Nanning Municipal No.4 People's Hospital,Nanning 530023,Guangxi,China)

机构地区：[1]南宁市第四人民医院感染外科,南宁530023 [2]南宁市第四人民医院麻醉科,南宁530023 [3]南宁市第四人民医院外科,南宁530023

出　　处：《中国性科学》2019年第12期106-109,共4页Chinese Journal of Human Sexuality

基　　金：南宁市科技攻关计划(20143145)

摘　　要：目的探讨HIV/AIDS合并外科疾病患者的外科手术治疗的分析。方法选取2014年1月1日至2016年12月31日南宁市第四人民医院诊治的112例HIV/AIDS合并外科疾病的患者作为研究对象。将患者按照HIV/AIDS治疗的规范性分为两组,规范性治疗组56例,未规范性治疗组56例。观察患者在进行外科手术后,其围手术期并发症及机会性感染情况;观察患者术前的血常规情况,比较各组患者术前术后CD4+、CD8+及CD4+/CD8+的变化。结果①与未规范性治疗组相比,规范治疗组患者的围手术期并发症的比例显著降低,差异具有统计学意义(P<0.05);与规范性治疗组相比,未规范性治疗组患者手术机会性感染率显著升高,差异具有统计学意义(P<0.01),且两组患者均在腹部感染与肺部感染的发生率占比最高,其次是带状疱疹与局部感染的比例较高;②与未规范性治疗组患者相比,规范性治疗组患者术后血常规结果是显著提升的,更接近正常值,差异具有统计学意义(P<0.05);③术前两组的CD4+、CD8+T淋巴细胞计数及CD4+/CD8+比值差异无统计学意义(P>0.05);但在术后,与规范治疗组相比,未规范治疗组患者术后的CD4+、CD8+T淋巴细胞计数显著下降,差异具有统计学意义(P<0.05);术后两组的CD4+/CD8+比值都是下降的,但未规范治疗组其下降显著,差异具有统计学意义(P<0.05)。结论规范性治疗能减少HIV/AIDS合并外科疾病患者外科手术时围手术期并发症的发生率,并且可以降低HIV/AIDS患者外科手术的机会性感染率,而且规范性治疗会改善术后患者的免疫力,提升患者术后的恢复效果。Objective To explore the analysis on surgical treatment for patients with HIV/AIDS complicated with surgical diseases. Methods 112 patients with HIV/AIDS complicated with surgical diseases in our hospital from January 1, 2014 to December 31, 2016 were selected and divided into the standard treatment group(n=56) and the non-standard treatment group(n=56). The perioperative complications and opportunistic infections of patients after surgery were observed. The preoperative blood routine examination results of the patients were observed, and the changes in CD4+, CD8+ and CD4+/CD8+ in each group were compared. Results ① Compared with the non-standard treatment group, the proportion of perioperative complications in the standard treatment group was significantly reduced, with statistically significant differences between the two groups(P<0.05). Compared with the standard treatment group, the incidences of opportunistic infection in the non-standard treatment group significantly increased(P<0.05) and both groups had the highest incidence of abdominal infection and pulmonary infection, followed by incidences of herpes zoster and local infection. ② Compared with patients in the non-standard treatment group, postoperative blood routine examination results of patients in the standard treatment group were significantly improved, closer to the normal value(P<0.05). ③There was no significant difference in preoperative CD4+, CD8+ T lymphocyte count and CD4+/CD8+ ratio between the non-standard treatment group and the standard treatment group(P>0.05). However, compared with the standard treatment group, the postoperative CD4+ and CD8+ T lymphocyte counts of patients in the non-standard treatment group were significantly decreased after surgery(P<0.05). The CD4+/CD8+ ratio was decreased in both groups, more significant in the non-standard treatment group with statistical significance(P<0.05). Conclusions Statndard treatment can reduce the incidence of perioperative complications in patients with HIV/AIDS complicated with su

关 键 词：HIV/AIDS 外科疾病 规范性治疗 机会性感染 CD4+ CD8+ 

分 类 号：R759[医药卫生—皮肤病学与性病学]