基础胰岛素制剂的区别：对延长作用机制的理解有助于解释制剂间的差异  

Differentiating Basal Insulin Preparations: Understanding How They Work Explains Why They Are Different

作　　者：张化冰[1] ZHANG Hua-bing(Department of Endocrinology,Peking Union Medical College Hospital,Beijing 100730,China)

机构地区：[1]北京协和医院内分泌科

出　　处：《药品评价》2019年第21期7-10,32,共5页Drug Evaluation

摘　　要：所有胰岛素在靶组织水平具有相同的作用机制,故通过不同延长作用时间的机制实现时间-作用曲线的差异,导致药物在皮下组织间隙的过程和进入循环的吸收速率不同。基于不同延长作用时间的机制和导致的临床作用曲线的差异,2019年5月发表在Adv Ther杂志上的文章“基础胰岛素制剂的区别:对延长作用机制的理解有助于解释制剂间的差异”对几种基础胰岛素制剂进行比较。通过综合利用这些知识,在确定哪种治疗方案最大程度满足每位患者的需求时,医疗保健专业人员和支付方可以做出知情和明智的决策。本文对该篇文章进行中文摘译,同时,特邀杨文英教授对此文做一点评。Given that all insulins have the same mechanism of action at the target tissue level,the differences in time-action profiles are achieved through different mechanisms of protraction,resulting in different behaviors in the subcutaneous space and different rates of absorption into the circulation.This article provided simple translation for the research article titled with“Differentiating Basal Insulin Preparations:Understanding How They Work Explains Why They Are Different”(published in Adv Ther,2019 May;36(5):1018-1030.doi:10.1007/s12325-019-00925-6.)and opinion by invited clinical experts.

关 键 词：基础胰岛素 低血糖 药效学 药代动力学 延长作用 第二代长效胰岛素 

分 类 号：R977.15[医药卫生—药品] R587.1[医药卫生—药学]