过敏原屋尘混合项hx2特异性IgE的检测结果分析  

Analysis of the detection results of allergen specific IgE for house dust mixture

作　　者：梁雪清[1] 韦妮莉[1] 黄惠敏[1] 胡海圣 孙宝清[1] LIANG Xueqing;WEI Nili;HUANG Huimin;HU Haisheng;SUN Baoqing(Department of Allergy,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou,Guangdong 510120,China)

机构地区：[1]广州医科大学附属第一医院变态反应科

出　　处：《国际检验医学杂志》2020年第3期331-334,338,共5页International Journal of Laboratory Medicine

基　　金：广东省医学科学技术研究项目(A2019224);广东省科技计划项目(2019B030316028);广州医科大学附属第一医院培育项目(ZH201818)

摘　　要：目的分析过敏原屋尘混合项(hx2)特异性血清免疫球蛋白E(sIgE)的阳性分布特征及hx2 sIgE与单项过敏原sIgE的相关性。方法收集2004年11月至2016年11月就诊于该院并用Immuno CAP过敏原检测系统检测过敏原hx2的患者2134例,分析其阳性分布特点及hx2 sIgE与单项过敏原[屋尘螨(d1)、粉尘螨(d2)、德国小蠊(i6)和屋尘(h1)]sIgE的相关性。结果hx2阳性率为41.6%,hx2 sIgE水平与4个单项过敏原sIgE水平均相关,其中hx2和d1、d2均高度相关(r=0.969、0.963,P<0.05),与h1中度相关(r=0.680,P<0.05),与i6弱相关(r=0.206,P=0.003)。d1、d2和h1 sIgE在hx2 sIgE为三级以上时阳性概率均升高。hx2 sIgE的阳性率随年龄变化,先上升后下降,学龄期达最高峰(79.0%)。在青壮年组和中老年组,男、女性的hx2 sIgE水平差异有统计学意义(P=0.003、0.007),而性别导致的hx2阳性率差异仅在青壮年组有统计学意义(P=0.014)。结论过敏原hx2与d1、d2、h1和i6均有不同程度相关,不同年龄和性别的hx2阳性分布存在差异,检测hx2能有效地筛查常见的吸入过敏原,临床诊断应根据不同患者的情况选择合适的过敏原检测方案。Objective To analyze the positive distribution characteristics of specific immunoglobulin E(sIgE)to house dust mixture(hx2)and the correlation between hx2 sIgE and single allergen sIgE.Methods From November 2004 to November 2016,2134 patients who were tested for the allergen hx2 with the Immuno CAP allergen detection system in the hospital were collected.The positive distribution characteristics and the correlation between hx2 sIgE and single allergen[house dust mite(d1),dust mite(d2),blattella germanica(i6)and house dust(h1)]sIgE were analyzed.Results The positive rate of hx2 was 41.6%.The concentration of hx2 sIgE was highly correlated with the concentration of four single allergens,among which hx2,d1 and d2 were highly correlated(r=0.969,0.963,P<0.05),moderately correlated with h1(r=0.680,P<0.05),weakly correlated with i6(r=0.206,P=0.003).The positive rates of d1,d2 and h1 sIgE were all increased when hx2 sIgE was above class 3.The positive rate of hx2 sIgE increased first and then decreased with age,and reached the peak in school age group(79.0%).In the young and middle-aged groups,the difference of hx2 sIgE concentration between men and women was statistically significant(P=0.003,0.007),while the difference of hx2 positive rate caused by gender was statistically significant only in the young and middle-aged group(P=0.014).Conclusion hx2 is related to d1,d2,h1 and i6 in different degrees.There are differences in the positive distribution of hx2 in different ages and genders.The detection of hx2 can effectively screen common inhaled allergens.In clinical diagnosis,the appropriate allergen detection scheme should be selected according to the situation of different patients.

关 键 词：屋尘混合项 过敏原 特异性免疫球蛋白E 

分 类 号：R446.6[医药卫生—诊断学]