注射用头孢哌酮钠他唑巴坦钠与输液配伍稳定性研究  

Study on Stability of Cefoperazone Sodium and Tazobactam Sodium for Injection in Glucose and Sodium Chloride Injection

作　　者：马亚松 李敏 贾玉捷 孙燕 杨宏硕 MA Ya-song;LI Min;JIA Yu-jie;SUN Yan;YANG Hong-shuo(NCPC Hebei Huamin Pharmaceutical Co.,Ltd.,Shijiazhuang 050000,China)

机构地区：[1]华北制药河北华民药业有限责任公司

出　　处：《化工管理》2020年第4期95-96,共2页Chemical Engineering Management

摘　　要：考察注射用头孢哌酮钠他唑巴坦钠与氯化钠溶液、葡萄糖溶液的输液配伍稳定性。将注射用头孢哌酮钠他唑巴坦钠与0.9%氯化钠注射液和5%葡萄糖注射液分别配伍,分别测定配伍液在室温条件下放置0、0.5、1、1.5h的含量、有关物质、pH值、不溶性微粒和可见异物的变化情况。注射用头孢哌酮钠他唑巴坦钠与输液配伍后,在室温下放置1h含量、有关物质、pH值、不溶性微粒和可见异物的变化均不显著。注射用头孢哌酮钠他唑巴坦钠与氯化钠注射液、葡萄制注射液等输液配伍后,在室温条件下放置1h质量稳定。Objective:To observe the stability of Cefoperazone Sodium and Tazobactam Sodium for Injection in glucose and sodium chloride injection.Methods:The contents of solutions,polymeric substance and related substances of Cefoperazone Sodium and Tazobactam Sodium for Injection in 0.9%sodiumchloride injection and 5.0%glucose injection.The content,related substances,thepH and insoluble particleswere measured.Then they were placed separately at room temperature for 0,0.5,1,1.5h.Resulita There were no obvious changes in the content,related substances,the pH and insoluble particles.Conclusion:The Cefoperazone Sodium and Tazobactam Sodium for Injection in glucose and sodium chloride injection is stable in 1h at room temperature.

关 键 词：注射用头孢哌酮钠他唑巴坦钠 输液配伍 稳定性 

分 类 号：R942[医药卫生—药剂学]