新疆地区666例泌尿生殖道支原体培养及药物敏感性分析  

Mycoplasma cultivation and antibiotic sensitivity analysis of 666 cases of urogenital tract in Xinjiang

作　　者：关猛猛[1] 靳颖[1] 冯萍萍[1] 康晓静[1] GUAN Mengmeng;JIN Ying;FENG Pingping;KANG Xiaojing(Department of Dermatology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830001,China)

机构地区：[1]新疆维吾尔自治区人民医院皮肤性病科

出　　处：《新疆医学》2019年第11期1091-1094,共4页Xinjiang Medical Journal

基　　金：新疆维吾尔自治区人民医院科技引进创新项目;（项目编号：20180304）

摘　　要：目的调查分析666例泌尿生殖道感染患者支原体感染情况及对抗菌药物的敏感性,为临床合理用药及流行病学统计提供依据。方法对666例泌尿生殖道感染患者进行支原体培养及药敏试验,分别对维吾尔族和汉族患者两组进行比较分析。结果在666份患者标本中,支原体阳性患者211例,阳性率31.68%。其中,男性患者阳性率24.40%,女性患者阳性率63.20%,女性支原体感染率明显高于男性;汉族患者阳性率25.60%,维吾尔族患者阳性率50.62%,维吾尔族泌尿生殖道感染患者支原体感染率显著高于汉族患者。阳性标本中,解脲脲原体(Uu)阳性占比81.99%,人型支原体(Mh)及Uu+Mh阳性占比分别为5.69%和12.32%。药敏试验结果显示,支原体属对交沙霉素、美满霉素、强力霉素敏感率均>90%;Uu对环丙沙星及氧氟沙星的耐药率较高,分别为67.05%和65.90%;Mh对环丙沙星及罗红霉素耐药率最高,分别为66.67%和50%;Uu+Mh对环丙沙星及氧氟沙星的耐药率最高,均>90%;维吾尔族对阿奇霉素敏感性高于汉族患者。结论本地区女性比男性更易受支原体感染;支原体感染以单纯Uu感染为主;与Uu相比,Mh和Uu+Mh感染后抗菌药物的敏感率有下降的趋势,耐药性有升高的趋势;交沙霉素、美满霉素以及强力霉可作为经验性治疗的首选药物。Objective To investigate the infection status and drug suscepetibility of mycoplasma from 666 patients with genital mycoplasma infection,and to provide the scientific bases for the clinical application of antibiotics.Methods Mycoplasma cultivation and antibiotic sensitivity test were carried out in 666 patients with urogenital tract infection.Results Among 666 samples,211 samples were mycoplasma positive,with a positive rate of 31.68%.Among them,the positive rate of male patients was 24.40%,the positive rate of female patients was 63.20%,female mycoplasma infection rate was significantly higher than that of male;the positive rate of Han patients 25.60%,the positive rate of Uygur patients was 50.62%,Uygur urogenital tract infection rate was significantly higher than that of Han patients.The positive rate of Uu was 81.99%,that of MH and Uu+Mh was 5.69%and 12.32%,respectively.The results of drug sensitivity test showed that the sensitivity rate of mycoplasma to josamycin,minocycline and doxycycline was more than 90%;the resistance rate of Uu to ciprofloxacin and ofloxacin was higher,67.05% and 65.90% respectively;the resistance rate of Mh to ciprofloxacin and roxithromycin was the highest,66.67% and 50% respectively;the resistance rate of Uu+Mh to ciprofloxacin and ofloxacin was the highest,90% respectively;the resistance rate of Uygur nationality to a was the highest.The sensitivity of qimycin was higher than that of Han patients.Conclusion Women in this area are more susceptible to mycoplasma infection than men.Mycoplasma infection is mainly due to Uu infection.Compared with Uu,the sensitivity rate of antibacterial drugs after Mh and Uu+Mh infection has a downward trend,and the drug resistance has an upward trend.Josamycin,minocycline and strongylomycin can be used as the first choice drugs for empirical treatment.

关 键 词：支原体 感染率 敏感性 抗菌药物敏感试验 

分 类 号：R446.5[医药卫生—诊断学]