凉血消疕汤联合钙泊三醇倍他米松软膏治疗寻常型银屑病的临床疗效观察  

Clinical observation of Liangxue Xiaobi decoction combined calcipotriol betamethasone ointment in the treatment of psoriasis vulgaris

作　　者：胡荣毅[1] 周飞红[1] 周小勇[1] HU Rong-yi;ZHOU Fei-hong;ZHOU Xiao-yong(Department of Dermatology,First Hospital of Wuhan,Wuhan 430022,Hubei Province,China)

机构地区：[1]湖北省武汉市第一医院皮肤科

出　　处：《世界临床药物》2019年第11期790-794,共5页World Clinical Drug

基　　金：国家重点研发计划“中医药现代化研究”重点专项(2018YFC1705304)

摘　　要：目的观察自拟方剂凉血消疕汤联合钙泊三醇倍他米松软膏外用治疗寻常型银屑病的临床疗效。方法纳入121例寻常型银屑病患者随机分为治疗组(n=62)和对照组(n=59)。两组均给予钙泊三醇倍他米松软膏外用,一日1次,治疗组在此基础上加用凉血消疕汤口服,一日1剂,两组均共治疗8周。分别于治疗前、治疗后2、4、6及8周评估患者银屑病面积和严重指数(psoriasis area and severity index,PASI)、瘙痒程度评分以评价疗效。结果疗程早期(治疗后2~4周)治疗组与对照组PASI评分比较差异无统计学意义(P>0.05);疗程后期(治疗后6~8周)与对照组比较,治疗组PASI评分明显下降(P<0.05)。治疗组总有效率77.42%,对照组总有效率57.63%,治疗组总有效率显著高于对照组(P<0.05)。两组治疗后瘙痒程度评分均较治疗前显著下降(P<0.05);组间比较显示,两组治疗后瘙痒程度评分无统计学差异(P>0.05)。结论自拟方剂凉血消疕汤联合钙泊三醇倍他米松软膏外用治疗寻常型银屑病疗效较好,安全性好,值得临床推广应用。Objective To observe the clinical effect of Liangxue Xiaobi decoction combined calcipotriol betamethasone ointment in the treatment of psoriasis vulgaris.Method A total of 121 patients with psoriasis vulgaris were randomly divided into treatment group (n=62) and control group (n=59).Both groups were treated by calcipotriol betamethasone,once a day.On this base,the treatment group added Liangxue Xiaobi decoction once a day.Both groups were treated 8 weeks.The psoriatic area and severity index (PASI) and pruritus degree were evaluated before treatment,and 2,4,6 and 8 weeks after treatment.Results There was no significant difference in PASI score between the treatment group and the control group in the early period of treatment (2~4 weeks after treatment,P>0.05).In the later period of treatment (6~8 weeks after treatment),the PASI score in the treatment group decreased significantly than that in the control group (P<0.05).The total effective rate of the treatment group was 77.42%,and that of the control group was 57.63%.The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05).The score of pruritus degree in the two groups after treatment was significantly lower than that before treatment (P<0.05).There was no significant difference in the score of pruritus degree between the two groups after treatment (P>0.05).Conclusion Liangxue Xiaobi decoction combined calcipotriol betamethasone ointment in the treatment of psoriasis vulgaris is effective,safe and worthy of promotion.

关 键 词：凉血消疕汤 钙泊三醇倍他米松软膏 寻常型银屑病 临床疗效 

分 类 号：R758.63[医药卫生—皮肤病学与性病学] R275.9[医药卫生—临床医学]