普萘洛尔治疗卡波西样血管内皮瘤及丛状血管瘤患儿的疗效及其对心功能影响  

Effect of propranolol on cardiac function in children with Kaposiform hemangioendothelioma and tufted angioma

作　　者：尉莉[1] 李丽[1] 张斌[1] 马琳[1] WEI Li;LI Li;ZHANG Bin;MA Lin(Department of Dermatological,Beijing Children’s Hospital,Capital Medical University,Beijing 100045,China)

机构地区：[1]首都医科大学附属北京儿童医院皮肤科,北京100045

出　　处：《世界临床药物》2019年第12期845-849,共5页World Clinical Drug

基　　金：首都卫生发展科研专项基金(2016-2093);北京市属医院科研培育计划(PX2016014);北京市医院管理局儿科学科协同发展中心专项(XTZD20180502)。

摘　　要：目的探讨应用普萘洛尔治疗卡波西样血管内皮瘤(Kaposiform hemangioendothelioma,KHE)及丛状血管瘤(tufted angioma,TA)对患儿心功能的影响。方法2015年10月至2019年9月,对23例皮肤型KHE及TA患儿进行研究,患儿均口服普萘洛尔治疗,疗程为3~51个月,剂量为一日1.5~2.0 mg/kg。每日给药2次,间隔12 h。所有患儿服药后定期复诊,根据症状改善情况调整用药。随访内容主要是评价疗效和不良反应。结果23例患儿中18例有效,有效率为78.26%。治疗时间与癌体改善程度呈正相关(R=0.86)。2例患儿因疗效欠佳停药。所有患儿中出现轻度心肌损害者17例,经对症治疗后均恢复正常。结论口服普萘洛尔治疗KHE及TA有较好疗效,长期应用安全性高,对患儿心功能无明显损害。Objective To investigate the effects of propranolol in the treatment of kaposiform hemangioendothelioma(KHE)and tufted angioma(TA)on cardiac function in children.Methods From October 2015 to September 2019,23 cases with skin lesions KHE and TA were researched.All children were treated with propranolol for 3~51 months.The dose was 1.5~2.0 mg/kg one day.Dosing twice daily,12 h apart.All cases were followed up regularly after taking the drug,and the medication was adjusted according to the improvement of symptoms.The follow-up content was mainly to evaluate the efficacy and adverse reactions.Results A total of 18 patients were effective of the 23 cases,with an effective rate of 78.26%.There was a positive correlation between the treatment time and the improvement of tumor(R=0.86).Two children discontinued due to poor efficacy.There were 17 cases of mild myocardial damage in all children,and returned to normal after symptomatic treatment.Conclusion Propranolol is effective in the treatment of KHE and TA.It is safe to take long and has no obvious damage to the cardiac function of children.

关 键 词：普萘洛尔 卡波西样血管内皮瘤 丛状血管瘤 心功能 

分 类 号：R729[医药卫生—儿科] R972[医药卫生—临床医学]