放射作业工人肝功能与染色体损伤水平的关联性研究  

Study on relationship between liver function and chromosome damage in radiation workers

作　　者：张璟 何金铜 李佩珠 吴耀英 吴少虹 黄东兴 徐郁 叶浩森 李晓亮 Zhang Jing;He Jin-tong;Li Pei-zhu;Wu Yao-ying;Wu Shao-hong;Huang Dong-xing;Xu Yu;Ye Hao-sen;Li Xiao-liang(Zhuhai Municipal Center for Prevention and Control of Chronic Diseases,Zhuhai 519000,China)

机构地区：[1]珠海市慢性病防治中心

出　　处：《中国工业医学杂志》2019年第6期443-445,共3页Chinese Journal of Industrial Medicine

摘　　要：目的探讨放射作业人员肝功能与染色体损伤水平的关联性。方法选取2017年12月至2018年7月珠海市443名无肝脏病史、工龄≥1年的在职放射人员作为观察组,202名拟接触放射性作业的工作人员作为对照组;收集一般信息并采集外周静脉血5 ml,应用比色法和胞质分裂阻滞试验分别检测血清肝功能指标和外周血淋巴细胞微核率,采用腹部B超进行肝脏疾病筛查,并计算频率比(FR)及其95%CI值。结果观察组中,γ-谷氨酰转肽酶(γ-GGT)升高者(>50 U/L)微核率[(0.76±1.43)‰]也显著升高(FR=2.59,95%CI为1.66~4.05,P<0.001),两者有明显的剂量-效应关系(P趋势<0.001);而ALT升高者(>40 U/L)微核率[(0.35±0.70)‰]显著降低(FR=0.54,95%CI 0.31~0.94,P=0.030),两者也呈明显的剂量-效应关系(P趋势=0.005);天门冬氨酸氨基转移酶(AST)、总胆红素(TBiL)、总蛋白(TP)、白蛋白(ALB)与微核率则未见有明显的剂量-效应关系(P趋势均>0.05)。对照组中未发现各肝功能指标与微核率的关联性。结论γ-GGT和ALT升高与放射人员染色体损伤水平有关联,放射人员肝功能异常与染色体损伤有一定相关性。Objective To investigate the relatedness between liver function and chromosome damage in radiation workers.Methods 443 radiation workers had one or more working age,but without liver diseases from Zhuhai city were selected as observation subjects,and other 202 workers without radiation exposure as controls.Then,the serum liver function indeices and peripheral blood lymphocytic micronucleus frequencies(LMF)for each individual were detected by colorimetry and cytokinesis-block micronucleus(CBMN)assay,respectively,the liver diseases were screened by abdominal B-ultrasound examination.All analyses were analyzed using SPSS 16.0 software.Results It was showed that in radiation workers with higherγ-GGT level also had higher lymphocytic MN frequencies than those with normalγ-GGT level(FR=2.59,95%CI:1.66~4.05,P<0.001);while,comparing with subjects with higher ALT,those radiation workers with normal ALT level had lower level of MN frequencies(FR=0.54,95%CI:0.31~0.94,P=0.030).However,no significant associations among above variants was found in controls,there was no significant association among AST,TBiL,TP,ALB and LMF.Conclusion The results suggested that there were some relationship between increased chromosome damage(LMF)and highγ-GGT level or low ALT level in radiation workers.

关 键 词：放射人员 γ-谷氨酰转肽酶(γ-GGT) 丙氨酸氨基转移酶(ALT) 染色体损伤 外周血淋巴细胞微核率(LMF) 肝功能 

分 类 号：R146[医药卫生—公共卫生与预防医学]