慢性子宫内膜炎影响女性生殖结局的相关机制探讨  

Mechanism of chronic endometritis affecting female reproductive outcome

作　　者：董鑫垚 王蔼明 DONG Xin-yao;WANG Ai-ming(Affiliated Hospital of Inner Mongolia University for Nationalities,Tongliao 028000;The Sixth Medical Center of the PLA General Hospital,Beijing 100048)

机构地区：[1]内蒙古民族大学附属医院,通辽028000 [2]中国人民解放军总医院第六医学中心,北京100048

出　　处：《生殖医学杂志》2020年第1期130-134,共5页Journal of Reproductive Medicine

基　　金：国家“十二五”科技支撑计划项目(2012BAI32B05);内蒙古民族大学研究生科研立项(NMDSS1772)

摘　　要：慢性子宫内膜炎(CE)与女性生殖预后密切相关。目前认为CE是一种子宫内膜结构和功能被破坏的持续性炎症过程,由于局部内膜炎性细胞浸润和炎症介质渗出会改变子宫内膜微环境,影响子宫内膜容受性,不利于胚胎着床,可能是反复移植失败、复发性流产的原因之一。多年来CE由于临床症状轻微、缺乏特异性而被临床医生所忽视,因此本文就CE的微生物学、免疫学以及CE可能影响女性妊娠结局的相关机制进行综述,以期为CE相关不孕症的早期诊断及治疗提供理论依据。Chronic endometritis(CE)is closely related to female reproductive prognosis.It is currently believed that CE is a persistent inflammatory process in which the structure and function of the endometrium are damaged.The infiltration of inflammatory cells and exudation of inflammatory mediators in the local endometrium can change the endometrial microenvironment and affect endometrial receptivity,which is not conducive to embryo implantation,and may be one of the reasons for repeated transplantation failure and recurrent abortion.CE has been neglected by clinicians due to the lack of specificity in clinical symptoms for many years.This paper reviews the inflammatory process and microbiology of CE,as well as the relevant mechanisms which may influence the pregnancy outcome of women,so as to provide theoretical basis for the early diagnosis and treatment of CE.

关 键 词：慢性子宫内膜炎 子宫内膜容受性 临床妊娠结局 蜕膜化 

分 类 号：R711.32[医药卫生—妇产科学]