瑞利光散射技术用于药物中盐酸米多君的测定  

Determination of midodrine hydrochloride in drugs-based on Rayleigh light scattering technology

作　　者：庞向东[1] 刘璐瑶 袁合 胥城城 江虹[1] PANG Xiang-dong;LIU Lu-yao;YUAN He;XU Cheng-cheng;JIANG Hong(College of Chemistry and Chemical Engineering,Collaborative Innovation Center for Green Development in Wuling Mountain Areas,Yangtze Normal University,Chongqing 408100,China)

机构地区：[1]长江师范学院化学化工学院武陵山片区绿色发展协同创新中心

出　　处：《化学研究与应用》2020年第1期113-117,共5页Chemical Research and Application

基　　金：重庆市教委科技基金项目(KJ1401226)资助;长江师范学院科技基金项目(2018XKY076)资助

摘　　要：建立快速、准确、灵敏的检测药物中盐酸米多君的瑞利光散射(RLS)新方法。在pH 4.55 Tris-盐酸溶液和十六烷基溴化吡啶鎓溶液中,盐酸米多君与坚绿FCF 反应生成三元离子缔合物,使体系的RLS信号显著增强并产生具有2 个强散射峰的新RLS 光谱。在最大RLS 峰364 nm 处,盐酸米多君的质量浓度在0.004~0.35 mg·L^-1范围内与缔合物的RLS 增强强度(ΔIRLS)呈线性关系,检出限(3Sb/S)为0.0031 mg·L^-1。加标回收率和相对标准偏差(RSD)(n=5)分别为98.3%~102% 和1.0%~1.3%。该法用于药物中盐酸米多君含量的测定,结果满意。A rapid,accurate,sensitive and new Rayleigh light scattering(RLS)method for the determination of midodrine hydrochloride was developed.In a Tris-hydrochloric acid solution of pH 4.55 and 1-hexadecylpyridinium bromide,midodrine hydrochloride reacted with fast green FCF to form a ternary ionic association complexes,which led to a distinctly enhanced of Rayleigh light scattering signal of system and produced a new Rayleigh light scattering spectrum with two strong scattering peaks.At the maximum RLS peak 364 nm,the mass concentration of midodrine hydrochloride in the range of 0.004 to 0.35 mg·L^-1 was linearly related to the RLS enhancement intensity(ΔIRLS)of the association complexes and the detection limit(3Sb/S)was 0.0031 mg·L^-1.The spike recovery and the relative standard deviation(RSD)(n=5)were found to be 98.3%~102% and 1.0%~1.3%,respectively.The method was applied to determine the contents of midodrine hydrochloride in commercially available midodrine hydrochloride drugs with the satisfactory results.

关 键 词：盐酸米多君 坚绿FCF 十六烷基溴化吡啶鎓 瑞利光散射 

分 类 号：O657.3[理学—分析化学]