绝经后骨质疏松症患者血清IL-33水平变化及临床意义  

Changes of serum IL-33 level and its clinical significance in patients with postmenopausal osteoporosis

作　　者：耿庆贺 王申 翟怀远 孙华北 邵礼武 武恒斌 李剑 徐国庆 翟娟 李本田 衡科[4] 郭开今 王进 GENG Qing-he;WANG Shen;ZHAI Huai-yuan;SUN Hua-bei;SHAO Li-wu;WU Heng-bin;LI Jian;XU Guo-qing;ZHAI Juan;LI Ben-tian;HENG Ke;GUO Kai-jin;WANG Jin(Department of Orthopedics,Pizhou Hospital Affiliated to Xuzhou Medical University,Xuzhou,Jiangsu 221300,China)

机构地区：[1]徐州医科大学附属邳州医院骨科,江苏徐州221300 [2]广西医科大学研究生院,广西南宁530021 [3]南京东瑞医院骨科,江苏南京210000 [4]南京医科大学附属常州二院骨科,江苏常州320412 [5]徐州医科大学附属医院骨科,江苏徐州221004

出　　处：《中国临床研究》2020年第1期66-68,共3页Chinese Journal of Clinical Research

基　　金：徐州医科大学校级科研课题项目资助(2018KJ23);徐州医科大学附属邳州医院2019年院科研基金(2019KY001)~~

摘　　要：目的探讨绝经后骨质疏松妇女血清白细胞介素(IL)-33水平变化及其临床意义。方法选取2019年1月至4月在徐州医科大学附属邳州医院骨科门诊就诊的绝经后骨质疏松症患者50例为观察组,同期健康体检的绝经后妇女50例为对照组。采用酶联免疫吸附法检测两组患者血清中IL-33水平。结果与健康体检组相比较,绝经后骨质疏松患者血清IL-33水平明显降低[(5. 43±2. 48) pg/ml vs (20. 12±3. 44) pg/ml,P <0. 01]。结论绝经后骨质疏松妇女血清IL-33水平较健康人显著降低,IL-33可能是一种重要的骨保护细胞因子,对诊治绝经后骨质疏松症有一定的指导作用。Objective osteoporosis( PMOP) and its clinical significance. Methods Fifty patients with PMOP admitting to Orthopedic Department of Pizhou Hospital Affiliated to Xuzhou Medical University from January to April 2019 were selected as observation group,and 50 healthy postmenopausal women were served as control group at the same period. By enzyme linked immunosorbent assay( ELISA),the serum level of IL-33 was detected in two groups. Results Compared with control group,the serum IL-33 level significantly decreased in observation group [( 5. 43 ± 2. 48) pg/ml vs( 20. 12 ± 3. 44) pg/ml,P < 0. 01].Conclusions The serum level of IL-33 in women with PMOP is significantly lower than that in healthy postmenopausal women. IL-33 may be an important cytokine of bone protection and has a certain guiding role in the treatment of PMOP.

关 键 词：白细胞介素33 绝经 骨质疏松 酶联免疫吸附 细胞因子 

分 类 号：R681[医药卫生—骨科学] R58[医药卫生—外科学]