血浆中D-dimer在正常妊娠及妊娠高血压疾病孕妇中的表达差异  

Differential expression of D-dimer in plasma in pregnant women with normal pregnancy and hypertensive disorder complicating pregnancy

作　　者：郭冰杰 杨彩梅 GUO Bing-jie;YANG Cai-mei(Department of Gynaecology and Obstetrics,Beijing Chinese Medicine Hospital of Shunyi Branch,Beijing 101300,China)

机构地区：[1]北京中医医院顺义医院妇产科

出　　处：《中国实验诊断学》2020年第1期48-51,共4页Chinese Journal of Laboratory Diagnosis

基　　金：国家卫生计生委医药卫生科技发展研究中心基金项目（W2016CWBJ04）

摘　　要：目的探讨血浆中D-二聚体((D-dimer,D-D)在正常妊娠及妊娠高血压疾病孕妇中的表达差异。方法采用便利抽样方法,研究时间为2016年2月到2018年2月,选择在此期间在北京中医医院顺义医院妇产科诊治的妊娠高血压疾病孕妇86例(HDCP组)与正常妊娠妇女80例(正常组),检测所有孕妇在分娩前、产后第1d、产后第3d、产后第7d的血浆D-D值,同时记录孕妇的常规血糖、肾功能与一般资料指标。结果 HDCP组的年龄、分娩孕周、孕次、产次、体重指数与正常组对比差异无统计学意义(P>0.05),HDCP组的收缩压与舒张压显著高于正常组(P<0.05)。两组的RBC、HGB、HCT与PLT值对比差异无统计学意义(P>0.05),HDCP组FBG、GHB、BUN、Cr等值显著高于正常组(P<0.05)。HDCP组分娩前和产后第1d、3d、7d的血浆D-D含量都显著高于正常组(P<0.05)。Spearman相关分析显示妊娠高血压疾病孕妇分娩前的血浆D-D含量与收缩压、舒张压、FBG、GHB、BUN、Cr都呈现显著正相关性(P<0.05)。分娩前血浆D-D含量对妊娠期高血压、轻度子痫前期、重度子痫前期诊断的最佳阈值为104.22ng/ml、148.24ng/ml和245.91ng/ml。结论妊娠高血压疾病孕妇中的血浆D-D含量显著高于正常妊娠妇女,提示孕妇有凝血功能亢进和血糖、肾功能异常,可作为妊娠高血压疾病诊断的有效指标。Objective To investigate the differential expression of D-dimer(D-D)in plasma in pregnant women with normal pregnancy and hypertensive disorder complicating pregnancy.Methods Used a convenient sampling method,From February 2016 to February 2018,86 cases with hypertensive disorder complicating pregnancy(HDCP group)and80 cases with normal pregnant women(normal group)were selected.The Plasma D-D values were tested before delivery,postpartum 1 d,postpartum 3 dand postpartum 7 din the all cases,and the routine blood glucose,renal function and general data of the cases were recorded.Results The age,delivery gestational weeks,pregnancy times,parity,body mass index compared between the two groups were no significant difference(P>0.05).The systolic blood pressure and diastolic blood pressure in the HDCP group were significantly higher than those in the control group(P<0.05).There were no significant difference in the RBC,HGB,HCT and PLT values compared between the two groups.(P>0.05),the values of FBG,GHB,BUN and Cr in HDCP group were significantly higher than those in normal group(P<0.05).The plasma D-D levels of HDCP group at before delivery,postpartum 1 d,postpartum 3 dand postpartum 7 d were significantly higher than that of normal group(P<0.05).Spearman correlation analysis showed that the cases with hypertensive disorder complicating pregnancy were significant positive correlation between D-D levels and systolic blood pressure,diastolic blood pressure,FBG,GHB,BUN and Cr(P<0.05).The optimal thresholds of plasma D-D level before delivery for diagnosis the hypertensive disorder complicating pregnancy,mild pre-eclampsia and severe preeclampsia were 104.22 ng/ml,148.24 ng/ml and 245.91 ng/ml.Conclusion The plasma D-D level in hypertensive disorder complicating pregnancy is significantly higher than that in normal pregnant women that suggests that pregnant women have hypercoagulability and blood sugar and kidney abnormal function,and it can be used as an effective indicator for the diagnosis of hypertensive disorder compl

关 键 词：血浆 D-二聚体 妊娠高血压疾病 

分 类 号：R714[医药卫生—妇产科学]