人羊膜细胞的免疫调节作用  

Immunomodulatory effects of human amnion cells

作　　者：程亚伟 罗熠 王诺鑫 肖建辉 CHENG Ya-Wei;LUO Yi;WANG Nuo-Xin;XIAO Jian-Hui(Institute of Medical Biotechnology,Affiliated Hospital of Zunyi Medical University,Zunyi Key Laboratory of Medical Biotechnolog,Zunyi 563003,China)

机构地区：[1]遵义医科大学附属医院医药生物技术研究所遵义市医药生物技术重点实验室

出　　处：《中国免疫学杂志》2020年第4期499-503,共5页Chinese Journal of Immunology

基　　金：国家自然科学基金项目(81460156,81660363)

摘　　要：胎盘来源的人羊膜细胞是干细胞治疗的理想种子细胞。从人羊膜分离出的上皮细胞和间充质细胞具有自我更新、多系分化、可植入性等优良特性。而且,人羊膜上皮细胞和间充质细胞均可通过细胞接触和旁分泌效应调节免疫细胞的增殖、分化、凋亡等过程,改善免疫微环境。本文综述了人羊膜细胞对免疫细胞和免疫相关细胞因子分泌的调节作用,展示了其在治疗慢性炎症性疾病和自身免疫性疾病中的巨大临床应用潜力。Human amniotic cells derived from placenta are ideal seed cells for stem cell therapy.Epithelial cells and mesenchymal cells isolated from human amniotic membrane have excellent characteristics such as self-renewal,multilineage differentiation,and implantability.Moreover,human amniotic epithelial cells and mesenchymal cells can regulate the proliferation,differentiation and apoptosis of immune cells through cell contact and paracrine effects,and improve the immune microenvironment.This article reviews the regulation effect of human amnion cells on immune cells and immune-related cytokine secretion.These progresses suggest that human amniotic cells have great potential for the treatment of chronic inflammatory and autoimmune diseases.

关 键 词：人羊膜细胞 细胞治疗 免疫调节 免疫细胞 免疫微环境 

分 类 号：R392[医药卫生—免疫学]