老年膜性肾病免疫抑制治疗的进展  

Progress of immunosuppressive therapy for membranous nephropathy among the elderly

作　　者：李学旺[1] Li Xuewang(Department of Nephrology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院肾内科

出　　处：《中国临床保健杂志》2020年第1期19-23,共5页Chinese Journal of Clinical Healthcare

摘　　要：老年膜性肾病与非老年膜性肾病临床表现类似,但是因老年肾脏的特点老年膜性肾病患者的肾功能损害较重、高血压患病者较多且显著,低血浆白蛋白的程度较年轻患者更为显著。未治疗的老年膜性肾病患者的肾功能下降较非老年患者更为显著、预后更差;而接受免疫抑制治疗后能改善预后,接受免疫抑制治疗者肾功能改变趋势与非老年膜性肾病患者相同。老年患者接受免疫抑制治疗的感染更为常见、因感染的住院率和死亡率高于非老年患者。本文介绍了老年膜性肾病的临床特点、免疫抑制治疗的方案以及预后,以期为临床提供指导。The clinical manifestations of membranous nephropathy(MN)in the elderly as well as non-elderly are similar,however the renal impairment is significant and the hypertension is more common and more significant In elderly patients due to the characteristics of elderly The hypoalbuminemia also more common and severe in elderly patients.The renal function of untreated elderly patients with MN decreased significantly and the prognosis was worse than that of non-elderly patients.When receiving immunosuppressive therapy,the prognosis was improved,and the renal function change trend was the same in elderly and non-elderly patients with membranous nephropathy.Infections in elderly patients receiving immunosuppressive therapy are more common and hospitalizations and deaths due to infection are higher than in non-elderly patients.This article introduces the clinical characteristics of membranous nephropathy in the elderly,the immunosuppressive treatment plan,and the prognosis in order to provide guidance for the clinical treatment.

关 键 词：肾小球肾炎 膜性 免疫抑制法 预后 衰老 老年人 

分 类 号：R47[医药卫生—护理学]