连续5年沈阳地区生殖道支原体感染监测及耐药性变迁  

Surveillance of Mycoplasma genitalis Infection and changes in drug resistance for five years in Shenyang

作　　者：王晓娜[1] 丛桂敏 曹作伟 佟成龙 Wang Xiaona;Cong Guimin;Cao Zuowei;Tong Chenglong(Department of Clinical Laboratory,ShenyangWomen and Children Hospital,Shenyang,Liaoning,110011,China)

机构地区：[1]沈阳市妇婴医院检验科

出　　处：《当代医学》2020年第6期20-23,共4页Contemporary Medicine

基　　金：辽宁省自然科学基金（20170540837）

摘　　要：目的了解沈阳地区生殖道支原体感染情况及耐药变迁,为临床合理使用抗生素治疗支原体感染提供科学依据。方法采用珠海市银科医学工程股份有限公司生产的支原体鉴定药敏试剂盒,对6705例疑诊患者进行Uu和Mh检测,并做耐药性分析。结果2014年1月至2018年12月支原体检测6705份标本,共检出支原体阳性4278例,阳性率为63.80%。其中单纯解脲支原体(Uu)阳性率55.90%(3748/6705),2014年至2018年阳性率分别为51.10%(303/593)、51.37%(711/1384)、57.25%(959/1675)、57.84%(940/1625)、58.26%(832/1428);解脲支原体与人型支原体混合感染(Uu+Mh)阳性率7.25%(486/6705),2014年至2018年阳性率分别为5.56%(33/592)、6.65%(92/1383)、7.46%(125/1675)、7.69%(125/1625)、7.77(111/1428);单纯人型支原体(Mh)阳性率0.70%(47/6705),2014年至2018年阳性率分别为0.67%(4/593)、0.57%(8/1384)、0.66(11/1675)、0.68(11/1625)、0.91%(13/1428)。按照不同性别支原体构成,女性患者阳性率占71.57%(3675/5135),男性患者阳性率占38.60%(606/1570)。6种药物中环丙沙星和氧氟沙星的耐药率最高,分别为75.50%和43.08%。两种药物耐药率亦呈逐年上升趋势,环丙沙星的耐药率从2014年的58.13%上升到2018年的81.10%,氧氟沙星的耐药率从2014年的14.06%上升到2018年的61.40%;罗红霉素和阿奇霉素耐药率五年间浮动不大,均<20%;交沙霉素、美满霉素则敏感率最高,分别为98.79%、98.07%。结论沈阳地区支原体感染及耐药性呈上升趋势,应重视支原体监测,并根据药敏试验的结果使用抗生素,避免耐药菌株继续增加,从而达到彻底治愈的目的。Objective To understand the situation of mycoplasma infection of genital tract and the change of drug resistance in Shenyang area,and to provide scientific basis for rational use of antibiotics in the treatment of Mycoplasma infection.Methods Uu and Mh tests were performed on 6705 suspected patients using the mycoplasma identification drug sensitivity kit produced by Zhuhai Yinke medical engineering Co.,Ltd.,and drug resistance analysis was performed.Results From January 2014 to December 2018,6705 samples of mycoplasma were detected,and a total of 4278 cases were positive for mycoplasma,with a positive rate of 63.80%.The positive rate of mycoplasma urealyticum(Uu)alone was 55.90%(3748/6705),and that from 2014 to 2018 was 51.10%(303/593),51.37%(711/1384),57.25%(959/1675),57.84%(940/1625),58.26%(832/1428),respectively.The positive rate of(Uu+Mh)infection was 7.25%(486/6705)and 5.56%(33/592),6.65%(92/1383),7.46%(125/1675),7.69%(125/1625)and 7.77%(111/1428),respectively.The positive rates of pure mycoplasma hominis(Mh)were 0.70%(47/6705),0.67%(4/593),0.57%(8/1384),0.66%(11/1675),0.68%(11/1625),and 0.91%(13/1428),respectively,from 2014 to 2018.According to the composition of mycoplasma of different genders,the positive rate of female patients accounted for 71.57%(3675/5135),and the positive rate of male patients accounted for 38.60%(606/1570).Among the 6 drugs,ciprofloxacin and ofloxacin had the highest drug resistance rate(75.50%and 43.08%,respectively).The drug resistance rate of the two drugs also showed an increasing trend year by year.The drug resistance rate of ciprofloxacin increased from 58.13%in 2014 to 81.10%in 2018,and the drug resistance rate of ofloxacin increased from 14.06%in 2014 to 61.40%in 2018.The drug resistance rates of roxithromycin and azithromycin were less than 20%in 5 years.The sensitivity rates were 98.79%and 98.07%respectively.Conclusion Mycoplasma infection and drug resistance are on the rise in Shenyang.We should pay attention to the detection of Mycoplasma and use antibiotics according t

关 键 词：解脲支原体 人型支原体 药物敏感试验 耐药性 

分 类 号：R446.5[医药卫生—诊断学] R691.3[医药卫生—临床医学]