双侧先天性重度感音神经性耳聋患儿低频振幅功能磁共振研究  

Low-frequency Amplitude Functional Magnetic Resonance Imaging in Children with Bilateral Congenital Severe Sensorineural Hearing loss

作　　者：陈桂玲[1] 杨明[1] 刘玉婷 吴寒 管红梅[1] CHEN Gguiling;YANG Ming;LIU Yuting;WU Han;GUAN Hongmei(Department of Radiology,Children's Hospital Affiliated to Nanjing Medical University,Jiangsu Nanjing 210008)

机构地区：[1]南京医科大学附属儿童医院

出　　处：《中华耳科学杂志》2020年第1期93-97,共5页Chinese Journal of Otology

基　　金：南京市医学科技发展项目(201605047)~~

摘　　要：目的研究应用静息态功能磁共振低频振幅方法分析双侧先天性重度感音神经性耳聋患儿脑功能磁共振改变。方法采集16例双侧先天性重度感音神经性耳聋患儿及20例正常听力儿童的静息态磁共振血氧水平依赖(blood oxygenation level dependent,BOLD)数据,对BOLD数据进行后处理,获得低频振幅(amplitude of low-frequency fluctuation,ALFF)图像,比较两组间ALFF信号得出两组间的差异性脑区。结果双侧先天性重度感音神经性耳聋组较正常听力儿童对照组ALFF增加且差异具有统计学意义(P<0.05)脑区包括左、右额中上回。双侧先天性重度感音神经性耳聋组较正常听力儿童对照组ALFF减低且差异具有统计学意义(P<0.05)脑区包括右后扣带回、右中央旁回。结论双侧先天性重度感音神经性耳聋患儿相关脑区的脑功能活动水平与正Gguiling,YANG Ming,LIU Yuting,WU Han,GUAN Hongmei(Department of Radiology,Children's Hospital Affiliated to Nanjing Medical University,Jiangsu Nanjing 210008常听力儿童不同提示耳聋患儿存在脑代偿性功能及相关脑区功能会发生改变及重组。Objective Low-frequency amplitude resting state functional magnetic resonance(fMRI)imaging was used to demonstrate brain function changes in children with bilateral severe sensorineural hearing loss.Methods A total of 16 children with bilateral severe sensorineural hearing loss were enrolled in this study,and 20 age-and sex-matched healthy children served as controls.All participants underwent blood oxygenation level dependent(BOLD)MRI scan.BOLD MRI data were processed to generate amplitude of low-frequency fluctuations(ALFF)images,which were then compared between patient and control groups using two-sample t-tests.Result Compared with the control group,bilateral superior and median frontal gyri showed increased ALFF in the patient group(P<0.05),while right posterior cingulate gyrus and central paragyrus showed decreased ALFF.Conclusion Our study shows that the functional activities of brain in children with bilateral severe sensorineural hearing loss are changed,and the function of the relevant brain regions may be altered and reorganized.

关 键 词：功能磁共振成像 ALFF 先天性感音神经性聋 儿童 

分 类 号：R764[医药卫生—耳鼻咽喉科]