康柏西普玻璃体内注射治疗特发性脉络膜新生血管  

Intravitreal injection of Conbercept in treatment of patients with idiopathic choroidal neovascularization

作　　者：宋晶[1] 熊杰[1] SONG Jing;XIONG Jie(Department of Ophthalmology,the First People’s Hospital of Lianyungang,Lianyungang 222000,Jiangsu Province,China)

机构地区：[1]连云港市第一人民医院眼科

出　　处：《眼科新进展》2020年第2期169-172,共4页Recent Advances in Ophthalmology

摘　　要：目的探究康柏西普玻璃体内注射治疗特发性脉络膜新生血管(idiopathic choroidal neovascularization,ICNV)的疗效。方法选择2016年1月至2018年1月我院眼科收治的ICNV患者146例(146眼)纳入研究,所有患者均行玻璃体内注射康柏西普治疗,测量治疗前后最佳矫正视力(BCVA)、眼压、黄斑中心凹脉络膜厚度(subfoveal choroidal thickness,SFCT)及上侧脉络膜厚度(superior choroidal thickness,SCT)、下侧脉络膜厚度(inferior choroidal thickness,ICT)、鼻侧脉络膜厚度(nasal choroidal thickness,NCT)、颞侧脉络膜厚度(temporal choroidal thickness,TCT),观察并评价脉络膜新生血管(CNV)渗漏情况,比较患眼治疗前后BCVA、眼压及各区域脉络膜厚度,以及患眼及对侧眼脉络膜厚度差异。结果与治疗前比较,患眼治疗后1 d、1个月时BCVA均显著提高(均为P<0.05)。患眼治疗前后眼压比较差异均无统计学意义(均为P>0.05)。随访12个月时患眼渗漏区面积较治疗前均有下降,CNV渗漏治疗有效率为80.82%。治疗前患眼SFCT、NCT 2.2 mm、TCT 2.2 mm、TCT 3.45 mm均显著高于对侧眼(均为P<0.05);治疗后12个月患眼各部位脉络膜厚度均较治疗前显著降低,差异均有统计学意义(均为P<0.05)。治疗过程中及治疗后均未见严重不良反应发生。结论玻璃体内注射康柏西普可改善ICNV患者视力,减少视网膜渗漏症状,降低SFCT,效果较好。Objective To investigate the curative effect of intravitreal injection of Conbercept in the treatment of idiopathic choroidal neovascularization(ICNV).Methods Totally 146 ICNV patients(146 eyes)admitted to our Ophthalmology Department from January 2016 to January 2018 were enrolled in the study.All patients underwent intravitreal injection of Conbercept.The best corrected visual acuity(BCVA),intraocular pressure(IOP),subfoveal choroidal thickness(SFCT),superior choroidal thickness(SCT),inferior choroidal thickness(ICT),nasal choroidal thickness(NCT)and temporal choroidal thickness(TCT)before and after treatment were measured.Leakage condition of choroidal neovascularization(CNV)was observed and evaluated.BCVA,IOP and choroidal thickness in each region,and difference in choroidal thickness between affected eyes and contralateral eyes were compared before and after treatment.The choroidal thickness of the affected eye and contralateral eye were compared.Results Compared with that before treatment,BCVA of the affected eyes significantly improved at 1 day and 1 month after treatment(both P<0.05).There were no significant differences in IOP of the affected eyes before and after treatment(both P>0.05).The leakage area of the affected eyes decreased after 12 months of follow-up.The response rate of CNV leakage treatment was 80.82%.The SFCT,NCT 2.2 mm,TCT 2.2 mm and TCT 3.45 mm of the affected eyes were significantly higher than those of the contralateral eyes(all P<0.05).Compared with that before treatment,the choroidal thickness in all sites of affected eyes significantly decreased at 12 months after treatment(all P<0.05).There were no serious adverse reactions during or after treatment.Conclusion Intravitreal injection of Conbercept can improve the visual acuity of ICNV patients,reduce the symptoms of retinal leakage,and reduce SFCT that has a good effect.

关 键 词：抗血管内皮生长因子 脉络膜新生血管 康柏西普 脉络膜厚度 

分 类 号：R773.4[医药卫生—眼科]