二胺单保护方法工艺的研究  

Study on the Technology of Diamine Monoprotection

作　　者：李振亚 刘志波 于芳[1] Li Zhenya;Liu Zhibo;Yu Fang(College of Chemistry,Chemical Engineering and Environmental Engineering,Liaoning Shihua University,Fushun Liaoning 113001,China;Fushun Petrochemical Beitian Shunda Company,Fushun Liaoning 113006,China)

机构地区：[1]辽宁石油化工大学化学化工与环境学部,辽宁抚顺113001 [2]抚顺石化北天顺达公司,辽宁抚顺113006

出　　处：《辽宁石油化工大学学报》2020年第1期31-34,共4页Journal of Liaoning Petrochemical University

基　　金：国家自然科学基金项目(21402078)

摘　　要：研究了一种二胺单侧保护构建酰胺键的策略,找到一种能够大量获得单一单侧保护二胺的工艺方法。在反应温度为0℃时,向二胺溶液中缓慢加入保护基团并无需催化剂合成N-(6-氨基己基)氨基甲酸叔丁酯,反应具有较强的选择性和较好的普适性。该工艺方法能够有选择性地、高效地得到单一氨基保护产物,过量的二胺可以回收利用,提高了原料利用率,是绿色环保型反应。A strategy for the formation of amide bonds with one side protection of diamine was reported.A method was found to obtain a large number of mono-side protective diamines.When the reaction temperature was 0℃,adding the protective group to diamine solution slowly did not need catalyst to synthesize tert-butyl N-(6-aminohexyl)carbamate.The reaction had strong selectivity and good universality.The reaction had strong selectivity and good universality.This process can selectively and efficiently obtain the single amino protection product.The excessive diamine can be recycled and utilized,which improves the utilization rate of raw materials.It is a green and environment-friendly reaction.

关 键 词：酰胺键 单一氨基保护 保护基团 绿色环保 

分 类 号：TE624[石油与天然气工程—油气加工工程]