硫醇保护的银簇制备及其荧光检测应用的进展  

Development of preparation of thiol-protected silver clusters and fluorescence detection applications

作　　者：毕明刚 张纪梅[1,2] 郝帅帅 谢博尧 BI Ming-gang;ZHANG Ji-mei;HAO Shuai-shuai;XIE Bo-yao(School of Chemistry and Chemical Engineering,Tianjin Polytechnic University,Tianjin 300387,China;State Key Laboratory of Hollow Fiber Membrane Materials and Process,Tianjin Polytechnic University,Tianjin 300387,China)

机构地区：[1]天津工业大学化学与化工学院,天津300387 [2]天津工业大学中空纤维膜材料与膜过程国家重点实验室,天津300387

出　　处：《材料工程》2020年第2期11-21,共11页Journal of Materials Engineering

基　　金：国家自然科学基金(21106101);天津市自然科学基金(12JCZDJC29500)

摘　　要：贵金属纳米簇具有独特的电子结构和荧光特性,可以作为荧光探针,广泛应用于生物标记、离子检测等领域。本文综述了硫醇保护的银簇的制备方法,包括自下而上法和自上而下法,重点从优化反应的还原动力过程,选择优良的硫醇配体,改变体系的pH值,严格控制反应过程中的刻蚀时间和反应温度等方面,介绍了关于硫醇保护的银簇制备的研究现状,对进一步研究提供了思路。同时,基于硫醇保护的银簇优异的荧光性质,介绍了在检测Cu^2+,Hg^2+,I^-等离子以及半胱氨酸等小分子方面的研究进展。最后指出,提高金属纳米簇的荧光量子产率和安全性,深入研究金属纳米簇与重金属离子、生物大分子的反应机理,探究高纯度、多样性的合金簇或过渡金属纳米簇的合成方法,实现高效率的基于硫醇保护的银簇荧光传感材料的制备是未来研究中的热门方向。Precious metal nanoclusters have unique electronic structure and fluorescent properties,and can be used as fluorescent probes in a wide range of applications such as biomarkers and ion detection.This paper reviews the preparation methods of thiol-protected silver clusters,including bottom-up and top-down methods,focusing on optimizing the reduction process of the reaction,selecting excellent thiol ligands,changing the pH values of the system,and strictly controlling.The research status of the preparation of thiol-protected silver clusters was introduced in terms of etching time and reaction temperature during the reaction,and ideas and suggestions for further research were provided.At the same time,based on the excellent fluorescence properties of thiol-protected silver clusters,the research progress in the detection of small molecules such as Cu^2+,Hg^2+,I-and cysteine was introduced.Finally,it was pointed out that the fluorescence quantum yield and safety of metal nanoclusters are improved,and the reaction mechanism of metal nanoclusters with heavy metal ions and biomacromolecules is studied in depth,and the synthesis methods of high purity and diversity alloy clusters or transition metal nanoclusters are explored.The preparation of fluorescent sensing materials for the realization of highly efficient thiol-protected silver clusters is a hot trend in future research.

关 键 词：银簇 纳米粒子 制备 荧光检测 

分 类 号：O657.3[理学—分析化学] TB333[理学—化学]