中药敷贴疗法对糖尿病足创面菌群的影响  

Effect of Traditional Chinese Medicine Application Therapy on Diabetic Foot Wound Flora

作　　者：于文霞[1] 王猛[1] 姚彬 刘爱茹 吕树泉[1] 杨振华 苏秀海[1] YU Wen-xia;WANG Meng;YAO Bin;LIU Ai-ru;LYU Shu-quan;YANG Zhen-hua;SU Xiu-hai(Hebei Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Cangzhou,Hebei Province,061001 China)

机构地区：[1]河北省沧州中西医结合医院

出　　处：《糖尿病新世界》2019年第24期15-16,共2页Diabetes New World Magazine

基　　金：2019年河北省中医药防治重大疑难疾病（糖尿病足）能力提升项目

摘　　要：目的观察甲珠黄连油膏敷贴疗法对糖尿病足中重度感染患者创面菌群及超敏C反应蛋白的影响。方法 2015年1月-2018年12月间选取该院收治的90例糖尿病足患者为研究对象,治疗组60例,用中药甲珠黄连油膏(该院制剂)创面周围敷贴与基础清创治疗;对照组30例,用基础清创治疗。每周观察创面菌群、创面面积、超敏C反应蛋白的变化,4周为1个疗程,疗程结束后,比较两组治疗前后有关指标。结果治疗后两组的创面菌群均能被抑制,创面面积缩小、超敏C反应蛋白明显降低,差异有统计学意义(P<0.01);其中治疗组创面菌群被抑制的时间较对照组明显缩短,差异有统计学意义(P<0.05)。治疗组创面面积缩小大于对照组,差异有统计学意义(P<0.05)。治疗组超敏C反应蛋白降低较对照组差异有统计学意义(P<0.05)。结论甲珠黄连油膏敷贴疗法联合基础清创治疗糖尿病足中重度感染患者优于单用基础清创治疗。Objective To observe the effect of Jiazhuhuanglian ointment on the wound flora and high-sensitivity C-reactive protein in patients with moderate to severe diabetic infection. Methods From January 2015 to December 2018, 90 patients with diabetic foot admitted to the hospital were selected as the research object. Sixty patients in the treatment group were treated with traditional Chinese medicine Jiazhuhuanglian ointment(the preparation of our hospital) around the wound and basal debridement treatment;30 cases in the control group were treated with basal debridement. Weekly observation of wound flora, wound area, and high-sensitivity C-reactive protein changes, 4 weeks for a course of treatment, after the end of the treatment, compare the two groups before and after treatment related indicators. Results After treatment, the wound flora of the two groups could be inhibited, the wound area was reduced, and the high-sensitivity C-reactive protein was significantly decreased(P<0.01). The time of inhibition of the wound flora in the treatment group was significantly higher than that of the control group, with statistical difference(P<0.05). The wound area of the treatment group was smaller than that of the control group, with statistical difference(P<0.05). The reduction of high-sensitivity C-reactive protein in the treatment group was statistically different from that in the control group(P<0.05). Conclusion Jiazhuhuanglian ointment application combined with basal debridement is superior to single-use debridement treatment in patients with moderate to severe diabetic infection.

关 键 词：糖尿病足 中重度感染 敷贴疗法 甲珠黄连油膏 

分 类 号：R587.2[医药卫生—内分泌]