4-硝基苯基-β-D-纤维二糖苷的合成  

Synthesis of 4-nitrophenyl-β-D-cellobioside

作　　者：胡亚丹 常新林 钟婷 张贺延昊 苏进[1] 张园园 HU Yadan;CHANG Xinlin;ZHONG Ting;ZHANG Heyanhao;SU Jin;ZHANG Yuanyuan(Teaching and Research Office of Organic Chemistry,School of Pharmacy,Beijing University of Traditional Chinese Medicine,Beijing 100049,China;Teaching and Research Office of Natural Medicinal Chemistry,School of Pharmacy,Fudan University,Shanghai 201203,China)

机构地区：[1]北京中医药大学药学院有机化学教研室,北京100049 [2]复旦大学药学院天然药物化学教研室,上海201203

出　　处：《药学服务与研究》2020年第1期16-18,共3页Pharmaceutical Care and Research

摘　　要：目的:研究4-硝基苯基-β-D-纤维二糖苷的合成方法。方法:以D-八乙酰纤维二糖、对硝基苯酚钠为原料,经乙酰化、溴代、相转移催化成苷、脱保护等步骤合成目标产物,并优化溴代纤维二糖的制备工艺和成苷反应条件。结果:通过此方法合成了4-硝基苯基-β-D-纤维二糖苷,总产率为36.2%。结论:合成方法简单、高效、反应温和、成本低,可为4-硝基苯基-β-D-纤维二糖苷更广泛的应用提供原料储备和技术支持。Objective:To study the synthetic method of 4-nitrophenyl-β-D-cellobioside.Methods:The target product was synthesized from D-octaacetyl cellobiose and sodium p-nitrophenol by acetylation,bromination,phase transfer catalysis and deprotection,and the preparation process and reaction conditions of bromocellobiose were optimized.Results:4-nitrophenyl-β-D-cellobioside was synthesized by this method,and the total yield was 36.2%.Conclusion:The synthetic method is simple and efficient,with mild reaction and low cost.It could provide material reserve and technical support for broad application of 4-nitrophenyl-β-D-cellobioside.

关 键 词：4-硝基苯基-β-D-纤维二糖苷 化学合成 相转移催化法 

分 类 号：R977.3[医药卫生—药品] R914.5[医药卫生—药学]