多指标综合加权评分法优选肾衰乙方的提取工艺  

Optimization of the extraction technology of Shenshuaiyi decoction by comprehensive evaluation of multiple indexes

作　　者：张冰冰 张春燕[2] 潘蓉蓉 陈杰[1] 路建饶[1] 朱建勇[2] ZHANG Bingbing;ZHANG Chunyan;PAN Rongrong;CHEN Jie;LU Jianrao;ZHU Jianyong(Department of Nephrology, Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200137, China;Central Laboratory,Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China)

机构地区：[1]上海中医药大学附属第七人民医院肾病科,上海200137 [2]上海中医药大学附属第七人民医院中心实验室,上海200137

出　　处：《药学服务与研究》2020年第1期23-27,共5页Pharmaceutical Care and Research

基　　金：上海市浦东新区卫生和计划生育委员会中医药科技创新项目(PDZY-2018-0801);上海市浦东新区临床中医高峰学科(PDZY-2018-0601);上海市卫生和计划生育委员会中医药科研课题(2018YQ001)

摘　　要：目的:优选肾衰乙方的提取工艺。方法:采用L9(34)正交设计,以大黄酸、大黄素、丹皮酚、落新妇苷、橙皮苷的含量及出膏率的综合评分为指标,考察料液比、提取时间、提取次数对提取效果的影响,优选肾衰乙方的最佳提取工艺。结果:根据综合评分的结果,优选出肾衰乙方的最佳提取工艺为加8倍水,提取3次,每次1 h。结论:该提取工艺准确可靠,可行性好,可用于肾衰乙方的工业化生产。Objective:To optimize the extraction technology of Shenshuaiyi decoction.Methods:The effects of solid-liquid ratio,extraction time and times on extraction technology were investigate by L(3)orthogonal test based on the contents of rhein,emodin,paeonol,astilbin,hesperidin and extraction yield.Results:Based on the results of comprehensive scores,the optimized extraction technology of Shenshuaiyi decoction was as follows:8 times volume water of formulated crude materia medica,extracted three times,each time for 1 h.Conclusion:The extraction technology is accurate,reliable and feasible for industrial production of Shenshuaiyi decoction.

关 键 词：肾衰乙方 提取工艺 正交试验 多指标综合加权评分法 

分 类 号：R943[医药卫生—药剂学]