咖啡酸苯乙酯抗肿瘤活性的研究进展  

Research Advances in Anti-Tumor Activity of Caffeic Acid Phenethyl Ester

作　　者：李焕平[1] 刘可微 郝玉琴[2] 朱永蒙[3] LI Huanping;LIU Kewei;HAO Yuqin;ZHU Yongmeng(department of pharmacy,inner mongolia baogang hospital,baotou 014010,china;department of dermatology,inner mongolia baogang hospital,baotou 014010,china;department of urinary andrology,inner mongolia baogang hospital,baotou 014010,china)

机构地区：[1]内蒙古包钢医院药学部,内蒙古包头014010 [2]内蒙古包钢医院皮肤科,内蒙古包头014010 [3]内蒙古包钢医院泌尿男科,内蒙古包头014010

出　　处：《医学综述》2020年第3期480-485,490,共7页Medical Recapitulate

摘　　要：咖啡酸苯乙酯(CAPE)是潜在的抗肿瘤活性天然产物,不仅能抑制多种肿瘤细胞的生长,还具有抗乳腺癌、胆管癌、结直肠癌、黑素瘤等癌细胞的活性。在乳腺癌中,CAPE在抑制癌细胞生长的同时对正常乳腺细胞无影响;在胆管癌中,除抗癌细胞增殖外其他器官对其有良好的耐受性。近年又在神经胶质瘤、卵巢癌、鼻咽癌等多种 肿瘤细胞中对CAPE进行了分子或动物实验研究,均显示具有较强的肿瘤抑制作用。CAPE主要通过抑制核因子κB, 诱导细胞周期阻滞,诱导肿瘤细胞凋亡等抑制肿瘤的生长,其通过多种信号通路实现抗癌作用。Caffeic acid phenethyl ester(CAPE) is a potential natural product of anti-tumor activity.It can not only inhibit the growth of a variety of tumor cells,but also has anti-cancer activity in breast cancer,cholangiocarcinoma,colorectal cancer,melanoma and other cancer cells.In breast cancer,CAPE inhibits the growth of cancer cells and has no effect on normal breast cells.In cholangiocarcinoma,other organs are well tolerated except for the proliferation of cancer cells.In recent years,molecular or animal experiments on CAPE have been carried out in various tumor cells such as glioma,ovarian cancer and nasopharyngeal carcinoma,all of which have shown strong tumor inhibition.CAPE inhibits tumor growth mainly by inhibiting nuclear factor-κB,inducing cell cycle arrest,inducing apoptosis of tumor cells,etc., achieving anticancer effects through various signaling pathways.

关 键 词：咖啡酸苯乙酯 蜂胶 抗肿瘤 核因子ΚB 

分 类 号：R979.1[医药卫生—药品]