多发性骨髓瘤肾病的诊治进展  

Progress in Diagnosis and Treatment of Multiple Myeloma Nephropathy

作　　者：彭彰婧 杨亦彬 PENG Zhangjing;YANG Yibin(Department of Nephrology,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,China)

机构地区：[1]遵义医科大学附属医院肾内科

出　　处：《医学综述》2020年第2期291-295,共5页Medical Recapitulate

摘　　要：多发性骨髓瘤(MM)主要表现为相关器官损伤以及血清钙浓度升高、肾功能损害、贫血、骨质破坏等。MM的进展可严重损伤患者的肾功能,导致MM肾病,影响患者的生存期。故了解MM肾病的病理学表现、病理机制、诊断标准有助于其治疗。早期主要采用皮质类固醇和烷化剂类治疗,近年来免疫调节药物(沙利度胺、来那度胺)和蛋白酶抑制剂硼替佐米也开始应用于MM肾病的治疗。除药物治疗外,还可采用自体造血干细胞移植和血液透析治疗。Multiple myeloma(MM) is mainly characterized by related organ damage and elevated serum calcium concentration, renal dysfunction,anemia,and bone destruction.With the development of MM,it can seriously damage the renal function of the patient,leading to MM nephropathy,affecting the patient′s survival.Understanding the pathological manifestations,mechanisms,and diagnostic criteria contributes to the treatment of MM nephropathy.In the early stage,corticosteroids and alkylating agents are mainly used.In recent years,immunomodulators such as thalidomide,lenalidomide and protease inhibitor bortezomib have also been applied to the treatment of MM nephropathy.In addition to medication,autologous hematopoietic stem cell transplantation and hemodialysis can also be adopted.

关 键 词：多发性骨髓瘤 多发性骨髓瘤肾病 肾损伤 游离轻链 血液透析 

分 类 号：R692[医药卫生—泌尿科学]