骨关节病时生物学标志物及软骨细胞程序性死亡研究进展  

Advances in Biological Markers And Programmed Cell Death of Chondrocytes During Osteoarthrosis

作　　者：鄂心蕊 席健峰 郭宇航[2] 李慧玲[2] 王宇超[2] 王晓红[2] 付艳军[2] 王勇[2] E Xinrui;Xi Jianfeng;Guo Yuhang;Li Huiling;Wang Yuchao;Wang Xiaohong;Fu Yanjun;Wang Yong(Jiamusi University,Jiamusi 154007,China;First Affiliated Hospital of Jiamusi University,Jiamusi 154007,China)

机构地区：[1]佳木斯大学,黑龙江佳木斯154007 [2]佳木斯大学附属第一医院,黑龙江佳木斯154007

出　　处：《山东化工》2020年第3期62-63,共2页Shandong Chemical Industry

基　　金：黑龙江省卫生计生委科研课题(课题编号2018-291)

摘　　要：骨关节病(OA)是一种主要以关节基质崩解、软骨细胞显著减少为特征的一种慢性、进行性疾病。运用生物学相关标志物可以定量或定性关节功能疾病的状况。研究发现,随着OA病程的延长软骨细胞也随之发生明显减少。因此本文通过检测OA时相应的生物学标志物从而对OA做出相应的诊断,并且对病情的进展情况进行监测同时对软骨细胞程序性死亡作一综述。Osteoarthrosis(OA)is a chronic,progressive disease characterized by disintegration of joint matrix and significant reduction of chondrocytes.The use of biologically relevant markers can quantify or characterize the condition of joint function diseases.The study found that chondrocytes also decreased significantly as the duration of OA increased.Therefore,this paper makes a corresponding diagnosis of OA by detecting the corresponding biological markers in OA,and monitors the progress of the disease and reviews the programmed cell death of chondrocytes.

关 键 词：骨关节病 生物学标志物 软骨细胞 程序性死亡 

分 类 号：R684[医药卫生—骨科学]