Biginelli反应条件研究进展  

Research Progress on Biginelli Reaction Conditions

作　　者：郭妍妍[1] 盛华[1] GUO Yan-yan;SHENG Hua(Inner Mongolia Medical University,Inner Mongolia Hohhot 010110,China)

机构地区：[1]内蒙古医科大学

出　　处：《广州化工》2020年第2期14-16,24,共4页GuangZhou Chemical Industry

摘　　要：Biginelli反应是最重要的多组分反应(Multicomponent reaction,MCRs)之一。其产物可作为抗癌药,抗疟药,抗HIV药。总结了Biginelli反应机理及反应条件的选择和反应溶剂的选择,反应机理包括亚胺路线、烯胺路线、Knoevenagel类型的反应路线,反应条件包括酸催化剂、离子液体、纳米催化剂、微波法、超声法。反应溶剂包括无溶剂、水、乙醇。期望得到产率高、反应条件简便、绿色无污染的Biginelli反应条件。The Biginelli reaction is one of the most important multicomponent reactions(MCRs).Its products are used as anticancer drugs,antimalarials and anti-HIV drugs.The Biginelli reaction mechanism,the choice of reaction conditions and the choice of reaction solvent were summarized.The reaction mechanism included the imine route,the enamine route and the Knoevenagel type reaction route.The reaction conditions included acid catalyst,ionic liquid,nanocatalyst,microwave method,and ultrasonic method.The reaction solvent included no solvent,water and ethanol.It was desirable to obtain Biginelli reaction conditions with high yield,simple reaction conditions and green non-contamination.

关 键 词：BIGINELLI反应 反应机理 反应条件 反应溶剂 

分 类 号：TQ460.6[化学工程—制药化工]