白介素-22在动脉粥样硬化和2型糖尿病中的作用  

IL-22 in Atherosclerosis and Type 2 Diabetes Mellitus

作　　者：徐侨 刘正霞[2] 鲁翔[1,2] XU Qiao;LIU Zhengxia;LU Xiang(Nanjing Medical University,Nanjing 211166,Jiangsu,China;Laboratory of Geriatrics,The Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,Jiangsu,China)

机构地区：[1]南京医科大学,江苏南京211166 [2]南京医科大学第二附属医院老年医学实验室,江苏南京210011

出　　处：《心血管病学进展》2019年第9期1260-1263,共4页Advances in Cardiovascular Diseases

基　　金：国家自然科学基金(81770440,81970374)

摘　　要：低度慢性炎症是动脉粥样硬化和2型糖尿病的可能发病机制。白介素-22在慢性炎症反应过程中起到重要作用,主要表现为白介素-22可调节动脉粥样硬化斑块的形成,抑制β细胞氧化应激和内质网应激,恢复胰岛素分泌作用以及对糖脂代谢调节的保护作用。现着重讨论白介素-22在动脉粥样硬化和2型糖尿病中发挥的作用和可能机制。Studies suggest that low-degree chronic inflammation is a possible mechanism for atherosclerosis and type 2 diabetes.Interleukin-22 plays an important role in the process of chronic inflammation,which can regulate the formation of atherosclerotic plaques,inhibitβ-cell oxidative stress and endoplasmic reticulum stress,restore insulin secretion,and protect regulation of glucose and lipid metabolism.This paper focuses on the role and possible mechanism of interleukin-22 on atherosclerosis and type 2 diabetes mellitus.

关 键 词：白介素-22 动脉粥样硬化 2型糖尿病 

分 类 号：R543.5[医药卫生—心血管疾病] R587.2[医药卫生—内科学]