高尿酸血症与H型高血压之间的年龄依赖性  

Correlation between hyperuricemia and type H hypertension in different age groups

作　　者：张丹丹 洪秀琴[2,3,4] 王佳[2,3,4] 李璟 曾丹[2,3,4] 陈建 ZHANG Dan-dan;HONG Xiu-qin;WANG Jia;LI Jing;ZENG Dan;CHEN Jian(*School of Public Health,University of South China,Hengyang Hunan 421001,China)

机构地区：[1]南华大学公共卫生学院,湖南衡阳421001 [2]湖南省人民医院,湖南长沙410005 [3]湖南省分子流行病学重点实验室,湖南长沙410005 [4]湖南师范大学转化医学研究所流行病学研究室,湖南长沙410005

出　　处：《现代预防医学》2020年第2期371-375,共5页Modern Preventive Medicine

基　　金：国家自然科学基金（81202281）;国家自然科学基金（81773530）

摘　　要：目的探讨湖南省社区居民高尿酸血症与H型高血压之间年龄依赖的关联性,为H型高血压防治提供科学依据。方法以整群抽样方法调查湖南省6个地区30~90岁的常住社区高血压居民,通过问卷调查、实验室检测血液生化指标及logistic回归分析统计学方法分析不同年龄层高尿酸血症与H型高血压之间的相关性。结果本研究纳入1395名研究对象,其中H型高血压86.6%。单因素分析结果显示,≤60岁人群,非高尿酸血症与高尿酸血症人群间H型高血压患病率、教育程度、BMI、ALT、STP、Cr、BUG、TG、VLDL的差异具有统计学意义(均P<0.05);>60岁人群,非高尿酸血症与高尿酸血症人群之间ALT、STP、Cr、BUG、TG、TC、VLDL差异具有统计学意义(均P<0.05)。logistic回归分析:伴有高尿酸血症使H型高血压事件的发生风险显著增加(P=0.001,OR=2.24,95%CI=1.37~3.67)。年龄分层,仅≤60岁人群,高尿酸血症是H型高血压事件的的独立危险因素(P=0.007,OR=2.36,95%CI=1.26~4.41)。交互作用分析结果显示:≤60岁,尿酸与性别、总蛋白、VLDL的交互作用影响H型高血压(女性:P=0.040,OR=0.826,95%CI=0.69~0.99;STP:P=0.028,OR=1.007,95%CI=1.001~1.012;VLDL:P=0.011,OR=1.183,95%CI=1.04~1.35);>60岁,尿酸仅与VLDL存在交互作用影响H型高血压(P<0.001,OR=1.698,95%CI=1.262~2.285)。结论≤60岁人群,高尿酸血症是H型高血压的独立危险因素。Objective The aim of this study was to explore the age-related association between hyperuricemia and H-type hypertension in community hypertension patients in Hunan province,and to provide evidence for prevention and treatment of H-type hypertension.Methods Cluster sampling method was used to investigate hypertension residents in the resident communities from 30 to 90 years old in 6 districts of Hunan province.Through questionnaires,laboratory blood biochemical indicators and logistic regression analysis,the correlation between hyperuricemia and H-type hypertension in different age groups was analyzed.Results A total of 1395 subjects were included in the study,of which H-type hypertension was 86.6%.Stratification of age,compared with non-hyperuricemia,the differences in marital status,education level,ALT,Cre,UA,TG,TC,VLDL and hey were statistically significant(P<0.05 for all)in≤60-year--old population.The differences between ALT,STP,Cre,BUG,TG,TC,VLDL between non-hyperuricemia and hyperuricemia population were statistically significant(P<0.05 for all)in>60-year-old population.Logistic regression analysis showed:the risk of hyperuricemia with H-type hypertension was signifcantly increased(P=0.001,OR=2.24,95%C1=1.37-3.67).However,only for those≤60 years old,hyperuricemia was an independent risk factor for H-type hypertension events(P=0.007,OR=2.36,95%CI=1.26-4.41).The results of interaction analysis showed that:for those≤60 years old,the interaction of uric acid with gender,total protein and VLDL affected H-type hypertension(Female:P=0.040,OR=0.826,95%CI=0.69-0.99;STP:P=0.028,OR=1.007,95%CI=1.001-1.012;VLDL:P=0.011,OR=1.183,95%Cl=1.04-1.35).For those>60 years old,uric acid only interacted with VLDL to affect H-type hypertension(P<0.0001,OR=1.698,95%CI=1.262-2.285).Conclusion Hyperuricemia(HUA)was an independent risk factor for H-type hypertension,but this rule only existed in people under the age of 60 years.

关 键 词：H型高血压 普通型高血压 同型半胱氨酸 高尿酸血症 

分 类 号：R181.3^+2[医药卫生—流行病学]