不同体质类型支原体肺炎患儿临床表现及Th1/Th2免疫应答特点  

Features on Clinical Manifestation and Th1/Th2 Immune Response of Mycoplasma Pneumoniae Pneumonia in Children with Different Constitution Types

作　　者：张海军[1] 董晓蕾 蔺萃[1] 房有福[1] 张洪玉 ZHANG Hai-jun;DONG Xiao-lei;LIN Cui;FANG You-fu;ZHANG Hong-yu(Department of Paediatrics,Yidu Central Hospital of Weifang,Shandong 262500;Department of Gynaecology f Chinese Medicine Hospital in Qingzhou City,Shandong 262500)

机构地区：[1]山东省潍坊市益都中心医院儿内科,山东262500 [2]山东省青州市中医院妇科,山东262500

出　　处：《中国中西医结合杂志》2020年第1期27-30,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：山东省中医药科技发展计划项目(No.2017-408)

摘　　要：目的观察不同中医体质类型支原体肺炎儿童的临床表现及Th1/Th2免疫应答的特点,探讨中医辨“质”论治的机制。方法120例支原体肺炎患儿,按照中医体质类型标准分为平和质组、阴虚质组、阳虚质组、气虚质组、痰湿质组、湿热质组,比较各组患儿的主要临床表现(包括发热例数、发热消退时间、咳嗽缓解时间、喘息例数、湿啰音例数和湿啰音消失时间)及Th1/Th2免疫应答指标(包括IL-2、IFN-γ和IL-4)。结果与平和质组比较,痰湿质组湿啰音发生比例增加,IL-4水平升高,咳嗽缓解时间和湿啰音消退时间延长(P<0.05);湿热质组出现发热、湿啰音比例增加,IL-4水平升高,发热消退时间及湿啰音消退时间均延长(P<0.05);阴虚质组、阳虚质组及气虚质组IL-2、IFN-γ水平降低(P<0.05),阴虚质组IL-4水平升高(P<0.05)。5组偏颇体质比较,湿热质组、阴虚质组发热例数多于阳虚质组(P<0.05),湿热质组发热消退时间长于其余4组(P<0.05);痰湿质组、湿热质组湿啰音例数高于其余3组(P<0.05),阴虚质组、阳虚质组及气虚质组IL-2、IFN-γ水平低于其余2组,阴虚质组、痰湿质组及湿热质组IL-4水平高于其余2组(P<0.05)。结论不同中医体质类型的支原体肺炎患儿在临床表现及Th1/Th2免疫应答上存在差异,为辨“质”治疗儿童支原体肺炎提供了一定的依据。Objective To observe the clinical manifestations and characteristics of Th1/Th2 immune response in children mycoplasma pneumoniae pneumonia(MPP)with different constitution types of Chinese medicine(CM).To explore the mechanism of differentiation of"quality"in CM.Methods A total of 120 children with MP were assigned to balaneed constitution group,yin deficiency constitution group,ya ng deficie ncy constitution group,qi deficiency con stituti on group,phlegm damp ness con stit ution group,dampness heat constitution group according to the standard of constitution type of CM.The main clinical manifestations(including the incidences of fever,relief time of fever,cough relief time,the incidences of wheezing,incidence of moist rales,and moist rale duration)and Th1/Th2 immune response indexes(ineluding IL-2,IFN-γ,and IL-4)were compared among groups.Results Compared with balanced constitution group,the incidenee of moist rales and the level of IL-4 were higher in phlegm dampn ess constituti on group.Meanwhile its cough relief time and moist rale durati on were Ion ger(P<0.05).The level of IL-4 and the incidences of fever and moist rales were higher in dampness heat constitution group.Meanwhile,its relief time of fever and moist rales were Ion ger(P<0.05).The levels of IL-2 and IFN-γ in yin deficiency constitution group,yang deficiency constitution group and qi deficiency constitution group were lower(P<0.05).The IL-4 level of yin deficiency constitution group was higher(P<0.05).By comparing the 5 groups of biased constitution,the results showed that the incidences of fever in dampness heat constitution group and yin deficiency constitution group were more than that of yang deficiency con stitutio n group(P<0.05).The fever relief time in damp ness heat con stitution group was Ion ger tha n the other four groups(P<0.05).The incidences of moist rales in phlegm dampness constitution group and dampness heat constitution group were higher than the other three groups(P<0.05).The levels of IL-2 and IFN-γ in yin deficiency cons

关 键 词：中医体质类型 支原体肺炎 临床表现 TH1/TH2免疫应答 

分 类 号：R725.6[医药卫生—儿科]