中性粒细胞CD11b对新生儿败血症诊断价值的系统评价和meta分析  

Diagnostic value of neutrophil CD11b for neonatal sepsis: a systematic review and meta- analysis

作　　者：那飞扬 刘东海[2] 徐晓红[2] 张蓉芳[2] NA Fei-yang;LIU Dong-hai;XU Xiao-hong;ZHANG Rong-fang(Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省妇幼保健院,甘肃兰州730050

出　　处：《现代预防医学》2020年第3期557-561,共5页Modern Preventive Medicine

摘　　要：目的系统评价和分析中性粒细胞CD11b(nCD11b)对新生儿败血症的诊断潜能。方法对8个医学数据库进行系统检索,包括PubMed、Cochranelibrary.Embase,Webofscience、CNKI、CBM、万方和维普,时间截止到2018年12月,纳入中英文发表的nCDllb对新生儿败血症的诊断试验研究,2名研究人员进行数据提取和质量评价后,采用stata软件进行统计分析。结果共纳入11个研究合计975例患者。合并敏感度为0.80(95%C/:0.71-0.87),特异度为0.91(95%C/:0.69-0.98)、阳性似然比为&80(95%C/:2.06-37.64)、阴性似然比为0.22(95%C/:0.13~0.36)、诊断比值比为39.95(95%C/:6.04-264.06)和ROC曲线下面积依次为0.88(95%CI-0.85~0.91)。Deek's漏斗图显示发表偏倚可能性较小(P=0.08)。结论目前的证据表明nCDllb对新生儿败血症具有较高的诊断价值和潜力。Objective To systematically review and analyze the diagnostic value of neutrophil CD11b(nCD11b)for neonatal sepsis.Methods A comprehensive literature search was performed in PubMed,Cochrane Library,Embase,Web of Science,CNKI,CBM,Wanfang and Vip databases for relevant citations.Up to December 2018,the study about nCD11b in the diagnostic test of neonatal sepsis published in Chinese and English was included,and then two workers reviewed the study,extracted the data,and assessed the quality of included studies.At last,data was analyzed by Stata.Results Eleven studies,accounting for 975 neonates,were included.The overall pooled sensitivity,specificity,PLR,NLR,DOR,and ROC were calculated as 0.80(95%CZ:0.71,0.87),0.91(95%CZ:0.69,0.98),8.80(95%CZ:2.06,37.64),0.22(95%CI:0.13,0.36),39.95(95%CI:6.04,264.06)and 0.88(95%CI:0.85,0.91),respectively.Deek's funnel plot indicated that there was less possibility of publication bias.Conclusions In this research,nCD11b has higher diagnostic value and potential for neonatal sepsis.

关 键 词：nCD11b 诊断潜能 新生儿 败血症 META分析 

分 类 号：R722.131[医药卫生—儿科]