骨髓形态学和血小板参数对免疫性血小板减少症患者的临床应用探究  

Bone marrow morphology and platelet parameters in diagnosis of immune thrombocytopenia

作　　者：贺飞[1] 王薇[1] 高海燕[1] HE Fei;WANG Wei;GAO Hai-Yan(Department of Hematology,The Second Affiliated Hospital of Harbin Medical University,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属第二医院血液内科

出　　处：《哈尔滨医科大学学报》2019年第4期425-428,共4页Journal of Harbin Medical University

基　　金：黑龙江省博士后科研基金(LBH-Z15129);哈尔滨医科大学中青年科研基金(KYCX2018-15)

摘　　要：目的探讨骨髓巨核细胞与外周血血小板参数变化在免疫性血小板减少症(ITP)鉴别诊断中的应用价值。方法研究设ITP患者组(50例)、非ITP患者组(47例)和健康人对照组(45例),分别检测ITP和非ITP组患者骨髓中巨核细胞及外周血血小板参数及健康对照组外周血血小板参数;采用t检测进行统计学分析。结果与非ITP组相比,ITP组患者骨髓中巨核细胞数量明显增加,其中幼稚巨、颗粒型巨核细胞明显增加,产板型巨核细胞明显减少,差异有统计学意义(P<0.01),而外周血血小板各参数两组间无差异(P>0.05)。ITP组和健康对照组相比,血小板数量和压积均明显降低,有统计学意义(P<0.01)。结论骨髓形态学及外周血小板相关参数,对ITP的诊断和鉴别诊断具有重要的参考价值。Objective To investigate the value of bone marrow megakaryocyte(BMK) and peripheral platelet parameter changes in differential diagnosis of immune thrombocytopenia(ITP). Methods The 97 patients were divided into 2 groups: ITP group(50 cases) and non-ITP group(47 cases), while 45 healthy volunteers were as healthy controls. The parameters of BMK and peripheral platelets of ITP and non-ITP patients,and parameters of peripheral platelets of healthy controls were detected and compared. Results As compared with non-ITP group, the BMK count in ITP group obviously increased,including the granular MK and pro-MK, While the thromocytogenic MK obviously decreased with statistical difference(P<0.01);the platelet related parameters in 2 groups did not show significant difference(P>0.05). As compared with healthy control group,the platelet level and PCT of peripheral blood in ITP group significantly decreased(P<0.01). Conclusion The bone marrow morphology and platelet parameters have important clinical value for diagnosis and differential diagnosis of ITP.

关 键 词：免疫性血小板减少症 巨核细胞 血小板 

分 类 号：R558.2[医药卫生—血液循环系统疾病]