七氟烷对不同年龄段开颅手术患儿罗库溴铵肌松恢复时间的影响  

Effects of Sevoflurane on Muscular Relaxation Time of Rocuronium Bromide in Children Undergoing Craniotomy at Different Ages

作　　者：刘殿臣[1] 孙月明 刘铁军 Liu Dianchen;Sun Yueming;Liu Tiejun(Tangshan People's Hospital,Hebei Tangshan 063000,China;Peking University First Hospital,Beijing 100034,Chirui;Affiliated Hospital of North China University of Science and Technology,Hebei Tangshan 063000,China)

机构地区：[1]河北省唐山市人民医院,河北唐山063000 [2]北京大学第一医院,北京100034 [3]华北理工大学附属医院,河北唐山063000

出　　处：《儿科药学杂志》2020年第1期27-29,共3页Journal of Pediatric Pharmacy

摘　　要：目的:探讨七氟烷对不同年龄段开颅手术患儿罗库溴铵肌松恢复时间的影响。方法:选择唐山市人民医院2015年2月至2017年6月收治的择期行开颅手术的患儿36例,根据年龄分为1~3岁组16例,4~6岁组12例,>6岁组8例。给予吸入七氟烷麻醉维持,待七氟烷呼气末浓度于1.3倍最低肺泡有效浓度(MAC)稳定40 min后,静脉注射罗库溴铵0.6 mg/kg,记录直接手术时间、罗库溴铵起效时间[给药完毕至第1个肌颤搐(T1)消失时间]、体内作用时间(T1从0~90%时间)、恢复指数(T2从25%~75%时间)、临床肌松时间(T1从0~25%时间)、高峰时间(T1从0~5%时间)和T1/T4值(TOFr)恢复到70%、90%的时间。结果:三组患儿均未继续追加罗库溴铵,组间肌松定标后各时间点的脑电双频指数(BIS)值比较差异无统计学意义(P均>0.05);三组间直接手术时间、起效时间、高峰时间、临床肌松时间、恢复指数、体内作用时间、TOFr 70%时间、TOFr 90%时间比较差异均无统计学意义(P均>0.05)。结论:1.3 MAC的七氟烷对不同年龄段儿童开颅手术罗库溴铵肌松恢复时间的影响差异无统计学意义。Objective:To investigate the effects of sevoflurane on muscular relaxation time of rocuronium bromide in children undergoing craniotomy at different ages.Methods:Thirty-six children undergoing craniotomy in Tangshan People’s Hospital from Feb.2015 to Jun.2017 were extracted.According to the age,there were 16 cases in the 1 to 3 year group,12 cases in the 4 to 6 year group,and 8 cases in the>6 years group.Inhalation of sevoflurane was given for anaesthesia.After the end-expiratory concentration of sevoflurane stabilized at 1.3 times of minimum alveolar concentration(MAC)for 40 min,rocuronium bromide was injected intravenously at 0.6 mg/kg.The direct operation time,onset time of rocuronium bromide(from completion of administration to the disappearance time(T1)of the first muscle twitch),in vivo action time(T1 from 0 to 90%time),recovery index(T2 from 25%to 75% time),clinical muscle relaxation time(T1 from 0 to 25% time),peak time(T1 from 0 to 5% time),and recovery time of T1/T4 ratio(TOFr)to 70% and 90% were recorded.Results:None of the three groups of children continued to be supplemented with rocuronium bromide,and there was no significant difference in bispectral index(BIS)at each time point among three groups after muscle relaxation calibration(P>0.05).There were no significant differences in direct operation time,onset time,peak time,clinical muscular relaxation time,recovery index,in vivo action time,TOFr 70%time,and TOFr 90% time among three groups(P>0.05).Conclusion:The difference of 1.3 times of MAC sevoflurane on the recovery time of muscular relaxation time of rocuronium bromide in children undergoing craniotomy at different ages were not statistically significant.

关 键 词：七氟烷 儿童 罗库涣铁 肌松恢复 

分 类 号：R726.1[医药卫生—儿科]