Interventional closure operation increases angiotensin-(1-7) level in pulmonary arterial hypertension due to congenital heart disease  

作　　者：戴海龙 杨强凤 光雪峰 尹小龙 

机构地区：[1]Key Laboratory of Cardiovascular Disease of Yunnan Province, Department of Cardiology, Yan’an Affiliated Hospital of Kunming Medical University

出　　处：《South China Journal of Cardiology》2019年第4期264-268,共5页岭南心血管病杂志（英文版）

基　　金：supported by the Projects of National Natural Science Foundation of China(No.81360037/No.81700438);Natural Science Foundation of Yunnan(No.2012FB019/No.2013FZ284);the Health Talent Program of Yunnan(No.H201611/No.2016-SW(sheng)-27/No.2018HB105)

摘　　要：Background Recent studies have demonstrated that angiotensin(Ang)-(1-7) plays an important role in the development of pulmonary arterial hypertension(PAH). Our previously study showed that serum Ang-(1-7) level was decreased in patients with PAH due to congenital heart disease(CHD). The present study aimed to investigate the changes of serum Ang-(1-7) before and after intervention closure. Methods fifty-nine patients with CHD were included. The patients were divided into non-PAH(group A), mild PAH(group B) and moderate PAH(group C). The serum Ang-(1-7) was detected by enzyme-linked immunosorbent assay(ELISA) at 1 day before operation and 2 days after operation. Results Before intervention closure, serum angiotensin-(1-7) level was significantly lower in group C than that in group A and group B. After intervention closure operation, serum Ang-(1-7) level was increased in group B and group C. Conclusion Serum Ang-(1-7) level is increased in PAH patients after interventional closure operation of CHD, which might be used as potential clinical biomarkers to evaluate the postoperative prognosis for these patients.[S Chin J Cardiol 2019;20(4):264-268]Background Recent studies have demonstrated that angiotensin(Ang)-(1-7) plays an important role in the development of pulmonary arterial hypertension(PAH). Our previously study showed that serum Ang-(1-7) level was decreased in patients with PAH due to congenital heart disease(CHD). The present study aimed to investigate the changes of serum Ang-(1-7) before and after intervention closure. Methods fifty-nine patients with CHD were included. The patients were divided into non-PAH(group A), mild PAH(group B) and moderate PAH(group C). The serum Ang-(1-7) was detected by enzyme-linked immunosorbent assay(ELISA) at 1 day before operation and 2 days after operation. Results Before intervention closure, serum angiotensin-(1-7) level was significantly lower in group C than that in group A and group B. After intervention closure operation, serum Ang-(1-7) level was increased in group B and group C. Conclusion Serum Ang-(1-7) level is increased in PAH patients after interventional closure operation of CHD, which might be used as potential clinical biomarkers to evaluate the postoperative prognosis for these patients.[S Chin J Cardiol 2019;20(4):264-268]

关 键 词：angiotensin-(1-7) pulmonary arterial hypertension congenital heart disease intervention closure 

分 类 号：R541.1[医药卫生—心血管疾病]