单核-巨噬细胞在抗中性粒细胞胞浆抗体相关性血管炎中作用的研究进展  

Recent advances in role of monocyte-macrophage in anti-neutrophil cytoplasmic antibody associated vasculitis

作　　者：安晓宁 陈永熙[1] AN Xiao-ning;CHEN Yong-xi(Department of Nephrology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院肾内科

出　　处：《上海交通大学学报（医学版）》2020年第1期123-127,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金（81470041,81000285）~~

摘　　要：抗中性粒细胞胞浆抗体(anti-neutrophil cytoplasmic antibody,ANCA)相关性血管炎(ANCA associated vasculitis,AAV)是一类全身性自身免疫性疾病。AAV以小血管壁的炎症或纤维素样坏死为病理基础,可累及多个器官系统,严重时可危及生命。单核-巨噬细胞是机体固有免疫系统中重要的细胞组分,包括血液中的单核细胞和组织中固定或游走的巨噬细胞。在不同组织器官中的单核-巨噬细胞参与AAV发病和疾病进展。文章就单核-巨噬细胞在AAV中的研究进展予以综述。Anti-neutrophil cytoplasmic antibody(ANCA)associated vasculitis(AAV)constitues a group of autoimmune diseases with poor prognosis.Inflammation and fibrinoid necrosis of the small vessels are the pathological features of the disease,and many organs and systems can be involved.Monocyte-macrophages are important to innate immune system.Monocyte-macrophage can respond rapidly to inflammation and participate in the progression of AAV.Recently,the role of monocyte-macrophage in AAV has been studied with great detail.This article reviews recent research progress of monocyte-macrophage in AAV so as to further understand the disease.

关 键 词：抗中性粒细胞胞浆抗体 抗中性粒细胞胞浆抗体相关性血管炎 单核细胞 巨噬细胞 

分 类 号：R392.12[医药卫生—免疫学]