形状记忆高分子材料在骨缺损修复再生领域的研究进展  

Research progress on shape memory polymers in bone defect repair and regeneration

作　　者：刘育豪 张陶[2] Liu Yuhao;Zhang Tao(State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of Oral and Maxillofacial Surgery,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China;State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&Dept.of General Dentistry,West China Hospital of Stomatology,Sichuan University,Chengdu 610041,China)

机构地区：[1]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院口腔颌面外科,成都610041 [2]口腔疾病研究国家重点实验室国家口腔疾病临床医学研究中心四川大学华西口腔医院全科门诊,成都610041

出　　处：《国际口腔医学杂志》2020年第2期219-224,共6页International Journal of Stomatology

基　　金：国家自然科学基金(81800947);中国博士后科学基金(2018M640930);四川大学华西口腔医院青年科学研究基金(WCHS-201706)~~

摘　　要：作为一种新颖的智能响应型生物材料,形状记忆高分子材料(SMP)已用于骨缺损修复研究。该类材料可在温度、水分等外界刺激下发生“初始态”与“临时态”之间的三维形状转变,可紧密充填骨缺损,改善了常规植入材料形状不匹配、植入难度大等缺点。此外,该类材料改性后可作为多孔性骨组织工程支架,用以装载各类生物活性因子及干细胞,促进缺损处新骨形成。SMP已在微创性、修复不规则骨缺损、促进骨缺损再生等方面展现出良好前景。本文对其目前在骨缺损修复中的原理、效应、性能优化等研究进展作一综述。As novel stimuli-responsive biomaterials,shape memory polymers(SMPs)have been used in bone defect repair.The 3D shape of these biomaterials can be switched between initial and temporary states under external stimuli,such as temperature changes and water contact,making them suitable for tightly fi lling bone defects and advantageous over traditional materials featuring shape mismatch and complicated implantation.In addition,modifi ed SMPs can be used as porous bone tissue engineering scaffolds to load various bioactive factors and stem cells for new bone formation.Recently,SMPs have shown promising prospects in minimal invasiveness,repairing irregular bone defects,and promoting bone defect regeneration.This review will discuss the current progresses of SMPs in bone tissue engineering,including their mechanism,biological effects,and performance optimization.

关 键 词：形状记忆 高分子材料 骨缺损 骨组织工程 

分 类 号：R318.08[医药卫生—生物医学工程]