肌动蛋白聚合抑制剂对细胞骨架的作用  

Effects of actin polymerization inhibitors on cytoskeleton

作　　者：刘琳 包广洁 LIU Lin;BAO Guangjie(College of Stomatology/Key Lab of Stomatology of State Ethnic Affairs Commission,Northwest University for Nationalities,Lanzhou,Gansu 730030,China)

机构地区：[1]西北民族大学口腔医学院/西北民族大学口腔医学国家民委重点实验室

出　　处：《重庆医学》2020年第4期654-659,共6页Chongqing medicine

基　　金：中央高校基本科研业务费资助课题（31920150238、31920170167）

摘　　要：肌动蛋白是一种在所有真核细胞中均存在的高度保守蛋白质,微丝是由球形肌动蛋白单体聚合形成的多聚物,是必不可少的细胞骨架成分,参与细胞运动、细胞分裂等许多重要的生物功能。破坏肌动蛋白的聚合可能对细胞结构和细胞运动产生巨大的影响,肌动蛋白聚合抑制剂可以作为对抗恶性细胞的潜在药物,可以有针对性地开展进一步研究。基于以上原因,本文对能够抑制肌动蛋白聚合的细胞松弛素、拉春库林、Swinholide A和星孢菌素进行了综述。Actin is a highly-conserved protein presents in all eukaryotic cells.Actin filament is polymer assembled by globular actin monomers,which is an indispensable part of cytoskeleton because it takes part in many important biological functions such as cell movement and division.The disruption of actin polymerization may deeply affect cell structure and cell movement.Actin polymerization inhibitors with the ability to disrupt the actin polymerization can be used as potential drugs against malignant cells,which needs to be further studied.For the above reasons,this paper reviewed the drugs which have the ability to disrupt the actin polymerization:cytochalasin,Latrunculin,Swinholide A and Staurosporine.

关 键 词：肌动蛋白类 细胞松弛素类 拉春库林 Swinholide A 星孢菌素 

分 类 号：R34[医药卫生—基础医学]