STAT3信号通路在心房颤动中的机制研究  

Mechanism of STAT3 Signaling Pathway in Atrial Fibrillation

作　　者：向杰 刘明鑫[1] 黄从新[1] XIANG Jie;LIU Mingxin;HUANG Congxin(Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan 430060,Hubei,China)

机构地区：[1]武汉大学人民医院心血管内科

出　　处：《心血管病学进展》2020年第1期22-26,共5页Advances in Cardiovascular Diseases

摘　　要：STAT3是STATs家族中重要成员之一,参与调控机体内各种生物学过程,近期有研究表明心房颤动发生后STAT3信号通路被大量激活,STAT3可通过血管紧张素Ⅱ、mi RNA、炎性因子和生长因子等在介导心房颤动发生的心肌纤维化、炎症和细胞凋亡等方面发挥重要作用,因此STAT3可能是心房颤动进展过程中的关键调节因素。现就STAT3信号通路与心房颤动这一疾病间的关联及在此基础上的调控机制做一综述,以期更深入地理解心房颤动的发生机制,为心房颤动的治疗提供更加全面的理论基础。STAT3 is one of the important members of the STATs family and is involved in regulating various biological processes in the body. Recent studies have shown that STAT3 signaling pathway is activated in large amounts after atrial fibrillation( AF). STAT3 plays an important role in myocardial fibrosis,inflammation,apoptosis,etc.,which mediate atrial fibrillation through angiotensin Ⅱ,mi RNA,inflammatory factors,growth factors,etc. Therefore,STAT3 may be a key regulator of atrial fibrillation progression. This article mainly reviews the relationship between STAT3 signaling pathway and atrial fibrillation and the regulation of this mechanism,in order to understand deeply the mechanism of atrial fibrillation and provide a more comprehensive theoretical basis for the treatment of atrial fibrillation.

关 键 词：心房颤动 STAT3 信号通路 

分 类 号：R541.75[医药卫生—心血管疾病]