心力衰竭时β3肾上腺素能受体与心律失常的研究进展  

β3-adrenergic Receptors and Arrhythmia in Heart Failure

作　　者：李如意[1] 刘延俊 杜荣品[1] LI Ruyi;LIU Yanjun;DU Rongpin(Department of Cardiology,The Peoples’Hospital of Hebei Province,Shijiazhuang 050051,Hebei,China)

机构地区：[1]河北省人民医院心内科

出　　处：《心血管病学进展》2020年第1期51-54,共4页Advances in Cardiovascular Diseases

摘　　要：心力衰竭是多种心血管疾病发展到终末期的一种临床综合征,心律失常是其常见并发症,并可增加心力衰竭患者的死亡率。β3肾上腺素能受体是β肾上腺素能受体的一种亚型,心力衰竭时β3肾上腺素能受体表达增加,且其信号转导通路的多个环节发生改变,并参与了心力衰竭及其心律失常的发生和发展。现将β3肾上腺素能受体与心力衰竭及其心律失常的研究进展做一综述。Heart failure is an end-stage clinical syndrome of many cardiovascular disease. Arrhythmia is a common complication and can increase the mortality of heart failure patients. β3-adrenergic receptor is an isotype of β-adrenergic receptor. The expression of β3-adrenergic receptor increased in heart failure,and many links of the signal pathway regulated by β3-adrenergic receptor changed during heart failure,which participated in the occurrence and development of heart failure and arrhythmia. This article focuses on research progress of heart failure,β3-adrenergic receptor and arrhythmia.

关 键 词：心力衰竭 Β3肾上腺素能受体 心律失常 

分 类 号：R541.6[医药卫生—心血管疾病] R541.7[医药卫生—内科学]