心力衰竭与心肌线粒体代谢  

Heart Failure and Myocardial Mitochondrial Metabolism

作　　者：季春影 张瑞英[2] JI Chunying;ZHANG Ruiying(The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China;Medical Critical Care Unit,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学附属第一医院,黑龙江哈尔滨150001 [2]哈尔滨医科大学附属第一医院内科危重症,黑龙江哈尔滨150001

出　　处：《心血管病学进展》2020年第1期63-66,共4页Advances in Cardiovascular Diseases

基　　金：哈尔滨市科技创新人才基金(2017RAXXJ064)

摘　　要：心力衰竭作为各种心脏疾病的严重表现或晚期阶段,是影响中国国民健康及社会经济的严重疾病之一;尽管治疗手段不断改进,心力衰竭的病死率和再住院率仍较高,需对其病理生理进行深入研究。近年来的研究更加关注心力衰竭与心肌线粒体生物代谢的关系,其中包括线粒体的动态平衡、代谢、氧化应激和线粒体代谢相关信号分子等,线粒体有望成为心力衰竭治疗的新靶点。现阐述心力衰竭时能量代谢与心肌线粒体的关系以及心力衰竭治疗中线粒体靶向治疗的重要性。As a serious manifestation or late stage of various heart diseases,heart failure is one of the serious diseases affecting the national health and social economy of China. Despite the continuous improvement of treatment methods,the mortality rate and rehospitalization rate of heart failure are still high,and it needs to be in-depth study of pathophysiology. In recent years,studies have focused more on the relationship between heart failure and myocardial mitochondrial biological metabolism,including mitochondrial dynamic balance,metabolism,oxidative stress and mitochondrial metabolism-related signaling molecules. Mitochondria are expected to become a new target for the treatment of heart failure. This article will describe the relationship between energy metabolism and myocardial mitochondria in heart failure and the importance of mitochondria-targeted therapy in the treatment of heart failure.

关 键 词：心力衰竭 能量代谢 线粒体 氧化应激 

分 类 号：R541.6[医药卫生—心血管疾病]