急性ST段抬高型心肌梗死患者PCI后血清EREG水平及其与预后的关系  

Serum EREG Level after PCI and Its Relationship with Prognosis in Patients with Acute ST-segment Elevation Myocardial Infarction

作　　者：郝明辉[1] 郭明[1] 唐宇[1] 杨婧[1] 柳子静[1] 闫蕊 李萍 郭金成[1] HAO Minghui;GUO Ming;TANG Yu;YANG Jing;LIU Zijing;YAN Rui;LI Ping;GUO Jincheng(Department of Cardiology,Beijing Luhe Hospital,Capital Medical University,Beijing 101100,China)

机构地区：[1]首都医科大学附属北京潞河医院心内科

出　　处：《心血管病学进展》2020年第1期102-106,共5页Advances in Cardiovascular Diseases

基　　金：北京市卫计委首发专项(2018-2-7082)

摘　　要：目的探究急性ST段抬高型心肌梗死(STEMI)患者经皮冠脉介入术后血清表皮调节素(epiregulin,EREG)水平及其与预后的关系。方法前瞻性选取2017年6月-2018年4月接受救治的182例STEMI患者作为研究对象。根据STEMI患者预后情况将其分为预后良好组(n=157)和预后不良组(n=25)。采用双抗体夹心酶联免疫吸附法检测STEMI患者血清EREG水平,并分析其与预后的关系。结果预后不良组血清EREG水平高于预后良好组,差异有统计学意义(P <0. 05)。血清EREG评估STEMI患者1年预后的ROC曲线下面积、敏感性和特异性分别为0. 931、100. 00%和84. 71%。EREG高水平组平均生存时间低于EREG低水平组,差异有统计学意义(P <0. 05)。Cox单因素和多因素分析结果显示年龄、舒张压、低密度脂蛋白胆固醇和EREG与STEMI患者预后关系密切。结论 STEMI患者血清EREG水平与预后关系密切,血清EREG水平较高提示其预后不良。Objective To investigate the relationship between serum epiregulin( EREG) levels after percutaneous coronary intervention and prognosis in patients with acute ST-segment elevation myocardial infarction( STEMI). Methods A total of 182 patients with STEMI who underwent treatment from June 2017 to April 2018 were prospectively selected. According to the prognosis of patients with STEMI,they were divided into a good prognosis group( n = 157) and a poor prognosis group( n = 25). The serum EREG level of STEMI patients was detected by double antibody sandwich enzyme-linked immunosorbent assay,and its relationship with prognosis was analyzed.Results Serum EREG levels in the poor prognosis group were higher than those in the good prognosis group,and the difference was statistically significant( P < 0. 05). The ROC area under curve,sensitivity and specificity of serum EREG in evaluating one-year prognosis of STEMI patients were 0. 931,100. 00% and 84. 71%,respectively. The mean survival time of the EREG high-level group was lower than that of the EREG low-level group,and the difference was statistically significant( P < 0. 05). Cox univariate and multivariate analysis showed that age,diastolic blood pressure,low-density lipoprotein cholesterol and EREG were closely related to the prognosis of patients with STEMI. Conclusion Serum EREG levels in patients with STEMI are closely related to prognosis. Higher serum EREG levels suggest a poor prognosis.

关 键 词：急性ST段抬高型心肌梗死 表皮调节素 预后 主要不良心血管事件 

分 类 号：R542.22[医药卫生—心血管疾病]