阻塞型睡眠呼吸暂停低通气综合征对颈动脉硬化的影响  

Effect of Obstructive Sleep Apnea-hypopnea Syndrome on Carotid Arteriosclerosis

作　　者：刘会苗[1] 杨青[1] 张展[1] 杨金雨 王海威[2] LIU Hui-miao;YANG Qing;ZHANG Zhan;YANG Jin-yu;WANG Hai-wei(a.Ultrasound Diagnosis Department,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Department of Otorhinolaryngology,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]郑州大学第五附属医院超声诊断科,河南郑州450000 [2]郑州大学第五附属医院耳鼻咽喉科,河南郑州450000

出　　处：《河南医学研究》2020年第3期397-399,共3页Henan Medical Research

摘　　要：目的探讨阻塞型睡眠呼吸暂停低通气综合征(OSAHS)对颈动脉硬化的影响。方法选取2014年4月至2016年12月于郑州大学第五附属医院就诊或住院并有打鼾、白天嗜睡症状的145例患者,根据呼吸暂停低通气指数(AHI)分为OSAHS组和非OSAHS组,检测患者动脉硬化指数(ASI)及颈动脉内膜中层厚度(IMT)。结果OSAHS组体质量指数及血压较非OSAHS组增高,最低血氧饱和度降低,差异有统计学意义(P<0.05)。OSAHS组ASI及IMT高于非OSAHS组,OSAHS组血压增高者ASI及IMT高于OSAHS组血压正常者及非OSAHS组血压增高者,差异有统计学意义(P<0.05)。OSAHS组中,经多元回归分析,血压、AHI是ASI及IMT的危险因素。结论OSAHS与颈动脉硬化有明显关系,是颈动脉硬化的危险因素。Objective To investigate the effect of obstructive sleep apnea-hypopnea syndrome(OSAHS)on carotid arteriosclerosis.Methods One hundred and forty-five patients were selected from the Fifth Affiliated Hospital of Zhengzhou University from April 2014 to December 2016,which had OSAHS symptoms such as snoring and daytime sleepiness.According to apnea hypopnea index(AHI),the patients were divided into OSAHS group and non-OSAHS group.The arteriosclerosis index(ASI)and carotid intima-media thickness(IMT)were examined.Results In OSAHS group,the body mass index and blood pressure were higher and the lowest oxygen saturation was lower than that in control group,and the differences were statistically significant(P<0.05).Compared with non-OSAHS group,the OSAHS group had significantly higher ASI and IMT,and the differences were statistically significant(P<0.05).The OSAHS group coexisted with hypertension had higher ASI and IMT than the OSAHS group with normal blood pressure and non-OSAHS group coexisted with hypertension,and the differences were statistically significant(P<0.05).The multiple regression analysis showed that blood pressure and AHI were risk factor of ASI and IMT in OSAHS group.Conclusion OSAHS was closely associated with carotid atherosclerosis,and it was the risk factor of carotid atherosclerosis.

关 键 词：阻塞型睡眠呼吸暂停低通气综合征 颈动脉硬化 动脉硬化指数 颈动脉内膜中层厚度 

分 类 号：R766[医药卫生—耳鼻咽喉科]