锥形束CT评价仙灵骨葆胶囊治疗绝经后女性牙周炎患者牙槽骨骨量的变化  

Effect of Xianling Gubao Capsule on alveolar bone mass in postmenopausal women with periodontitis: a cone-beam CT evaluation

作　　者：张钰晶[1] 彭于治[1] 刘宝珍[1] 井芳[1] Zhang Yujing;Peng Yuzhi;Liu Baozhen;Jing Fang(Department of Stomatology,the First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine,Guiyang 510000,Guizhou Province,China)

机构地区：[1]贵阳中医学院第一附属医院口腔科

出　　处：《中国组织工程研究》2020年第17期2694-2699,共6页Chinese Journal of Tissue Engineering Research

基　　金：贵州省科技合作计划项目(黔科合LH字[2015]7287号)，项目负责人：井芳~~

摘　　要：背景:仙灵骨葆胶囊具有减少骨质流失、促进成骨细胞生成作用,在骨质疏松骨折中疗效已经得到初步证实,但在绝经后女性牙周炎的疗效尚未阐明。目的:应用锥形束CT技术评价仙灵骨葆胶囊对绝经后妇女牙周炎患者牙槽骨骨量的影响,为临床治疗提供有效依据。方法:选择2015年10月至2017年4月贵阳中医学院第一附属医院口腔科诊治的135例牙周炎患者,随机分为空白组、对照组、试验组(基础治疗+仙灵骨葆胶囊),各45例。所有患者接受口腔卫生健康教育、指导患者正确刷牙方法、自我控制菌斑,实施龈上洁治、龈下刮治、根面平整等以消除菌斑及牙石的牙周病基础治疗,每3个月进行一次,连续治疗6个月。对照组同时口服钙尔奇-D(每片含钙600 mg、维生素D 125 U),1片/次,1次/d,连续治疗6个月;试验组口服仙灵骨葆胶囊1.0 g/次,3次/d,3个月为一疗程,连续治疗2个疗程。采用锥形束CT检测患者治疗前、治疗3个月、治疗6个月牙槽骨缺损高度及骨密度的变化。试验已于2015-05-29获得贵阳中医学院第一附属医院伦理会批准(编号:K2015-186)。结果与结论:①与治疗前相比,试验组和对照组患者治疗后牙槽骨缺损高度显著缩小(P<0.05),骨密度显著增高(P<0.05),空白组牙槽骨缺损高度及骨密度均无变化(P>0.05),试验组牙槽骨缺损高度和骨密度改善程度高于对照组(P<0.05);②随着年龄增长,牙周炎病情加重,牙槽骨缺损高度逐渐增加,骨密度逐渐降低(P<0.05),与治疗前相比,46-50岁组患者治疗后牙槽骨缺损高度和骨密度均显著改善(P<0.05),51-55岁组患者骨密度增加明显(P<0.05),牙槽骨缺损高度无显著改变(P>0.05),>55岁组牙槽骨缺损高度、骨密度均无变化(P>0.05);③轻度和中度牙周炎患者牙槽骨缺损高度和骨密度均显著改善(P<0.05),重度牙周炎患者牙槽骨缺损高度和骨密度变化的差异无显著性意义(P>0.05);④�BACKGROUND:Xianling Gubao Capsule can reduce bone loss and promote the formation of osteoblasts.Its efficacy in osteoporosis and fracture has been preliminarily confirmed,but its efficacy in postmenopausal female periodontitis has not been clarified.OBJECTIVE:To assess the effect of Xianling Gubao Capsule on alveolar bone mass in postmenopausal women with periodontitis by cone-beam CT,providing an effective basis for its clinical use.METHODS:One hundred and thirty-five patients with periodontitis diagnosed and treated in the Department of Stomatology,First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine from October 2015 to April 2017 were enrolled.All patents were randomly divided into blank group(basic treatment),control group(basic treatment+vitamin D)and experimental group(basic treatment+Xianling Gubao Capsule),with 45 patients in each group.All patients received oral hygiene and health education,and were guided to brush their teeth correctly and self-control plaques.Basic treatments for periodontal disease were performed to eliminate plaque and calculus by cleaning and curing the gums,and smoothing the root surface,once 3 months for 6 continuous months.The control group received oral Calci-D(600 mg of calcium and 125 U of vitamin D per tablet),one tablet per day,for 6 continuous months.The experimental group was orally given Xianling Gubao Capsule 1.0 g/time,3 times per day,3 months as a course of treatment,for two consecutive courses.Cone-beam CT was used to detect the changes of bone mineral density and height of alveolar bone defect in all patients before treatment,3 and 6 months after treatment.Ethics approval was obtained from the First Affiliated Hospital of Guiyang College of Traditional Chinese Medicine on May 29,2015(approval No.K2015-186).RESULTS AND CONCLUSION:(1)Compared with the baseline,the alveolar bone defect height was significantly reduced in the experimental and control groups(P<0.05),and bone mineral density was significantly increased in the two groups(P<0.05).The

关 键 词：锥形束CT 仙灵骨葆胶囊 绝经后妇女 牙周炎 牙槽骨骨量 牙槽骨高度 骨密度 牙周重建 

分 类 号：R453.9[医药卫生—治疗学] R285.6[医药卫生—临床医学]