三四岁儿童基底核团的三维形态学特点  

Three-dimensional morphological characteristics of basal nuclei in children aged 3 or 4

作　　者：许阳阳 高尚 苏宝科 王一丹 和雨洁 李琨 王海燕 李筱贺 Xu Yangyang;Gao Shang;Su Baoke;Wang Yidan;He Yujie;Li Kun;Wang Haiyan;Li Xiaohe(Graduate School,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Department of Anatomy,Basic Medical School,Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China)

机构地区：[1]内蒙古医科大学研究生学院,内蒙古自治区呼和浩特市010110 [2]内蒙古医科大学基础医学院解剖教研室,内蒙古自治区呼和浩特市010110

出　　处：《中国组织工程研究》2020年第17期2724-2729,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81460330)，项目负责人：李筱贺;国家自然科学基金(81560348,81260269);内蒙古教育厅青年科技英才项目(njyt-15-b05)，项目负责人：李筱贺;内蒙自治区科技计划项目(2016)，项目负责人：李筱贺;内蒙古自治区科技创新引导项目(2017)，项目负责人：李筱贺;内蒙古自治区自然科学基金(2016ms08131)，项目负责人：李筱贺;内蒙古人社厅归国留学人员基金(TKD2017KJBW012)，项目负责人：李筱贺;内蒙古医科大学科技百万计划基金项目(YKD2017KJBW012)，项目负责人：王海燕~~

摘　　要：背景:国内外对于成人大脑基底核团的研究较多,多借助影像学手段测量,而关于三四岁儿童基底核团形态学三维重建与测量甚少。目的:建立三四岁儿童基底核团的三维立体模式,与其他年龄段进行比较,为探讨基底核团的神经发育提供形态学依据。方法:选取三四岁儿童尸体15例,薄层切割基底核团,并完成其主要结构精确分割的图像数据集;分析各断面标本主要结构的横断面,在特定断面测量相关结构的径线和角度,比较侧别间差异;对原始数据进行重新采样,建立基底核团三维空间坐标系。测量基底核团主要结构的形态大小,明确解剖标识,量化空间信息,建立模型和公共参考系统;三维立体显示基底核团结构,对于各个结构赋以不同颜色,清晰显示其各结构间边界,并行任意角度旋转切割,观测其内部结构。研究方案的实施符合内蒙古医科大学的相关伦理要求。标本均为儿童监护人自愿捐献并签署“知情同意书”。结果与结论:①获得儿童标本基底核团的连续横断面图像信息,通过重建获得其三维模型,重建结构不仅可显示其基底核团,测量基底核团体积、经线相关参数,侧别间差异无统计学意义;②所得三维重建结构可行任意角度、不同速度旋转,并可行相应的缩放及透明处理,使重建结构图像更加真实和逼真;③基于体绘制重建三四岁儿童基底核团为神经立体定向导航手术及癫痫等诊治提供形态学依据。BACKGROUND:There are many studies on the morphology of basal nuclei of adult brain based on various imaging methods,but little is reported on the three-dimensional reconstruction measurement of basal nucleus morphology in children aged 3 or 4.OBJECTIVE:To establish a three-dimensional model of the basal nucleus in children aged 3 or 4 years relative to other age groups in order to explore the morphological basis for the neurodevelopment of the basal nucleus.METHODS:Fifteen cadavers of 3 or 4 years old children were selected and the basal nucleus was cut by thin layer.The image data set with accurate segmentation of its main structure was then completed.The cross sections of the main structures were analyzed,the diameter and angle of the related structures were measured in a specific section,and the differences between the sides were compared.The original data were re-sampled to establish a three-dimensional coordinate system of the basal nucleus.The morphological size of the main structure of the basal nucleus was measured,the anatomical identification was clearly identified,and the spatial information was quantified.Model and the public reference system were established.The base nucleus structures were presented three-dimensionally and dyed in different colors.The boundary between the structures was clearly displayed,and the internal structure was observed by rotating and cutting at any angle.The study protocol was implemented in line with the relevant ethical requirements of Inner Mongolia Medical University.Specimens were donated voluntarily,and children’s guardians signed informed consents.RESULTS AND CONCLUSION:(1)The reconstructed three-dimensional model could show the basal nucleus,and could be used to measure the volume of the basal nucleus and the related parameters of meridians.There was no significant difference between the sides of the reconstructed model.(2)The reconstructed three-dimensional structure could be rotated at any angle and at different speeds,and the corresponding scaling and transpare

关 键 词：大脑基底核团 三维重建 解剖学测量 三四岁儿童 

分 类 号：R446[医药卫生—诊断学] R496[医药卫生—临床医学]