不同中草药提取物对耐甲氧西林金黄色葡萄球菌抑菌效果研究  

Comparison of Antibacterial Effects of Different Chinese HerbalExtracts on Drug-resistant Staphylococcus aureus

作　　者：刘承鑫 崔明全 颜本立 张辉华 王鹤佳[2] 朱馨乐[2] 刘燊 李秀梅[4] 王健春[4] 林树茂 LIU Cheng-xin;CUI Ming-quan;YAN Ben-li;ZHANG Hui-hua;WANG He-jia;ZHU Xin-le;LIU Sen;LI Xiu-mei;WANG Jian-chun;LIN Shu-mao(College of Life Science and Engineering,Foshan University,Foshan,Guangdong 528231,China;China Institute of Veterinary Drug Control,Beijing 100081,China;Guangdong Benyuan Technology Development Co.,Ltd.,Guangzhou,Guangdong 510650,China;Tianjin Animal Preventive and Control Center,Tianjin 300402,China)

机构地区：[1]佛山科学技术学院生命科学与工程学院,广东佛山528231 [2]中国兽医药品监察所,北京100081 [3]广东奔源科技发展有限公司,广东广州510650 [4]天津市动物疫病预防控制中心,天津300402

出　　处：《中国兽药杂志》2020年第1期53-58,共6页Chinese Journal of Veterinary Drug

基　　金：国家重点研发计划(2018YFC1200100);广东省教育厅高校科研项目(2017GCZX006);国家重点研发计划项目课题(2018YFD0500305)。

摘　　要：为了检测不同中草药提取物对耐甲氧西林金黄色葡萄球菌(MRSA)的抑菌效果,选取了7种不同粉碎粒度的中草药进行试验。用水提取法制备提取液,通过微量肉汤稀释法测定各提取液的抑菌效果。结果表明,厚朴、白术、茵陈提取液对金黄色葡萄球菌具有较强的抑菌活性;细粒度的厚朴提取液对MRSA的抑菌效果比粗粒度的厚朴提取液好。由此可见,厚朴提取物对MRSA具有潜在的抗菌优势。In order to test the antibacterial effect of different Chinese herbal extracts on Methicillin-resistant Staphylococcus aureus(MRSA),seven Chinese herbal medicines with different particle sizes were selected for the test.The extracts were prepared by water extraction method,and the bacteriostatic effects of the extracts were determined by micro-broth dilution method.The results showed that the extracts of Magnolia officinalis,Atractylodes macrocephala and Capillary artemisia had strong antimicrobial activity against Staphylococcus aureus,and the antimicrobial effect of fine-grained Magnolia officinalis extracts on MRSA was better than that of coarse-grained Magnolia officinalis extracts.Therefore,Magnolia officinalis extract is a potential antibacterial agent for MRSA.

关 键 词：中草药 耐甲氧西林金黄色葡萄球菌(MRSA) 粉碎粒度 抑菌效果 

分 类 号：S859.79[农业科学—临床兽医学]