微系统中细胞分选方法浅析  

Methods for Sorting Cells in Microsystems

作　　者：李备 张来明[1] 李文杰[1,2] 杨畅 Li Bei;Zhang Lai-ming;Li Wen-jie;Yang Chang(Changchun Institute of Optics,Fine Mechanics and Physics,Chinese Academy of Sciences,Jilin Changchun130033;HOOKE Instruments Co.Ltd.,Jilin Changchun 130033)

机构地区：[1]中国科学院长春光学精密机械与物理研究所,吉林长春130033 [2]长春长光辰英生物科学仪器有限公司,吉林长春130033

出　　处：《生物化工》2020年第1期133-134,137,共3页Biological Chemical Engineering

摘　　要：近十年来,研究人员广泛将微加工与微流体技术相结合,应用于细胞生物学。利用这些新技术,已经对干细胞、免疫细胞、癌症、神经元等进行了深度的研究。在应用微技术平台的各种生物和医学领域中,细胞分离技术于分类或寻找循环肿瘤细胞(CTCs)、血细胞分离等方面受到了高度重视。细胞分离微系统的不断发展将为诊断CTCs、癌症转移以及血液中的其他元素带来新的途径。基于此,介绍近年来形成的细胞分离微系统的物理原理,为工程师开发多样化分离系统提供理论依据。In the last decade,researchers have combined micromachining and microfluidics technologies for a wide range of applications in cell biology.Stem cells,immune cells,cancer,neurons and so on have been studied in depth using these new technologies.In a variety of biological and medical fields using microtechnology platforms,cell separation techniques have received great attention in the classification or search for circulating tumor cells(CTCs),blood cell separation and other aspects.The continued development of cell separation Microsystems will lead to new ways of diagnosing CTCs,cancer metastasis,and other elements in the blood.Based on this,the physical principle of cell separation microsystem formed in recent years is introduced to provide theoretical basis for engineers to develop diversified separation system.

关 键 词：细胞分选 激光与物质相互作用 可视化分选 

分 类 号：R197.39[医药卫生—卫生事业管理]